Dissertation (Metadaten)
Titel:In vitro - Identifizierung fettassimilationsinhibierender Bioaktivität
 
Autor:Niels Peter Möller
 
URN:NBN:urn:nbn:de:gbv:8-diss-20063
 
Fakultät:Agrar- und Ernährungswissenschaftliche Fakultät
DDC Sachgebiet:570 Biowissenschaften, Biologie
 
Datum der mdl. Prüfung:08.02.2007
 
Referent(in):Prof. Dr. med. J. Schrezenmeir
Korreferent(en) Korreferentin:Prof. Dr. med. vet. S. Wolffram
 
Beschreibung (original):Keine deutschsprachige Zusammenfassung vorhanden.
 
(übersetzt):The aim of this study was to identify substances by in vitro trials which lower postprandial triglycerides by their ability to inhibit pancreatic lipase or the intestinal fatty acid uptake. One of the 24 most effective lipase inhibitory test substances is Tabebuia impetiginosa (Lapacho tea), a tea manufacture of the inner bark of the amazonian taheebo tree. It inhibited the lipase strongly in vitro. In addition, this extract resulted in a significant reduction of postprandial triglycerides in subsequent animal trials with Wistar rats [personal information by Jürgen Schrezenmeir]. The effect of several synthetic PPARgamma- und PPARalpha ligands was investigated on palmitic acid uptake in Caco-2 cells. Only the incubation of the PPARalpha agonist GW7647 in the concentration 1 µmol/L resulted in a low but significant inhibition of palmitic acid uptake (p = 0,027). Natural PPARgamma and PPARalpha ligands are not applicable for the delay of fatty acid uptake in the intestine. Lapacho tea was identified as a promising candidate for the development of functional food or food additives for the Metabolic Syndrome.
 
Schlagworte:Lipidstoffwechsel ; Enzyminhibitor
Metabolic Syndrome, lipase inhibition, Orlistat, functional food, Caco-2, fatty acid uptake, PPAR ligands, Lapacho tea
 
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