@PhdThesis{diss_mods_00000542,
  author = 	{Grobe, Olaf},
  title = 	{Funktionelle Charakterisierung des p53-Zielgens IEX-1 durch ribozymvermittelte Inhibition der Genexpression},
  year = 	{2002},
  publisher = 	{Christian-Albrechts-Universit{\"a}t zu Kiel},
  address = 	{Kiel},
  keywords = 	{Hammerhead-Ribozyme; Zellzyklus; Apoptose; pBabePuro},
  abstract = 	{The early response gene IEX-1 modulates apoptosis and cell growth in a poorly defined fashion. Here, we describe the effect of hammerhead ribozymes specifically disrupting IEX-1 expression in 293 cells. Compared to vector control, 293 cells exhibit a reduced growth rate and a slowed cell cycle progression, when stably transfected with a concatemeric ribozyme construct. In addition, these 293 cells were much less sensitive to apoptosis induced by an activating Fas/CD95 antibody or by the anti-cancer drugs etoposide and doxorubicin. By modulating the cell cycle, IEX-1 might be part of a growth signal if favourable growth conditions prevail, whereas under unfavourable conditions, i.e. death receptor activation, IEX-1 facilitates apoptosis.},
  url = 	{https://macau.uni-kiel.de/receive/diss_mods_00000542},
  file = 	{:https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/dissertation_derivate_00000542/d542.pdf:PDF},
  language = 	{de}
}