000K utf8 1100 $c2006 1500 ger 2050 urn:nbn:de:gbv:8-diss-17418 3000 Pichert, Lars 4000 Wirkstoffkristallisate und proliposomal verkapselte Wirkstoffe aus überkritischer Gasphase$hChristian-Albrechts-Universität zu Kiel [Pichert, Lars] 4030 Kiel$nChristian-Albrechts-Universität zu Kiel 4209 The aim of this study on the one hand was to evaluate the micronisation of budesonide at various process conditions in the ASES-process. Thereby the obtained results show that the varied parameters CO2 flow rate and solution feed rate did hardly influence the micronisation process. On the other hand the feasibility of the micronisation of formoterol with supercritical carbon dioxide in the ASES-process was investigated. For these purposes the process parameters pressure and temperature in the ASES-process were varied as well as the drug solvents. Another aspect of this work was the development of liposomes in a dry reconstitutable form. Also in this case the ASES-process should act as an alternative to the standard liposome preparation methods. For these purposes different compositions consisting of lecithin, cholesterol and budesonide were precipitated under various conditions in supercritical carbon dioxide. 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8-diss-17418$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/diss_mods_00001741 5051 610 5550 Arzneimittel 5550 Mikronisation 5550 Zerkleinerung