PT Unknown
AU Biethahn, K
TI Regulation of Fc epsilon receptor I-mediated mast cell degranulation
PY 2011
PU Christian-Albrechts-Universität zu Kiel
WP https://macau.uni-kiel.de/receive/diss_mods_00006878
LA en
DE mast cells; degranulation; adaptor proteins; microRNA; miR-155; SAMSN1; Mastzellen; Adapterproteine
AB Mast cells (MCs) play an important role in acute inflammatory and allergic immune reactions. The activation of MCs via antigen-mediated triggering of the high-affinity IgE receptor FceRI causes immediate degranulation and release of preformed mediators from secretory granules, as well as de novo synthesis of lipid mediators and cytokines. The regulation of this complex process is crucial for the maintenance of a balanced immune system. Therefore, the goal of this study was to understand the regulatory mechanisms underlying MC activation, in particular the role of adaptor protein SAMSN1 and microRNA miR-155.
PI Kiel
ER