@PhdThesis{diss_mods_00013173,
  author = 	{Ling, Qi},
  title = 	{MicroRNAs encode the diversity between pancreatic head and body/tail cancers},
  year = 	{2013},
  publisher = 	{Christian-Albrechts-Universit{\"a}t zu Kiel},
  address = 	{Kiel},
  keywords = 	{pancreatic cancer; tumor location; diversity; microRNA},
  abstract = 	{Different clinical outcome has been found between pancreatic head cancer and pancreatic body/tail cancer. MicroRNAs (miRNAs) have been reported to play a potent functional role in the complex functional pathway networks controlling important cellular processes including tumor progression and invasion. To identify miRNA signatures that may encode a difference, microarrays comprising 887 human miRNAs in strictly matched early stage (I-II) pancreatic body/tail cancers and head cancers were performed and the results were further verified by qRT-PCR. We found remarkably down-regulated miR-501-3p and up-regulated miR-375 expressions in pancreatic body/tail cancer compared with head cancer. The recurrence rate was obviously lower in pancreatic body/tail cancer, and the down-regulation of miR-501-3p was significantly associated with low-risk of recurrence after curative surgery. By in vitro study, we provided first evidence that miR-501-3p could promote invasion of PDAC cells (Panc-1 and Colo357) possibly via decreasing the expression of E-Cadherin. Our results suggest that pancreatic body/tail cancer might be `less' malignant than pancreatic head cancer and two miRNAs (miR-501-3p and -375) may encode this diversity.},
  url = 	{https://macau.uni-kiel.de/receive/diss_mods_00013173},
  file = 	{:https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/dissertation_derivate_00005061/MD_thesis_from_QILING_(final_version).pdf:PDF},
  language = 	{en}
}