000K utf8 1100 $c2013 1500 eng 2050 urn:nbn:de:gbv:8-diss-131738 3000 Ling, Qi 4000 MicroRNAs encode the diversity between pancreatic head and body/tail cancers$hChristian-Albrechts-Universität zu Kiel [Ling, Qi] 4030 Kiel$nChristian-Albrechts-Universität zu Kiel 4209 Different clinical outcome has been found between pancreatic head cancer and pancreatic body/tail cancer. MicroRNAs (miRNAs) have been reported to play a potent functional role in the complex functional pathway networks controlling important cellular processes including tumor progression and invasion. To identify miRNA signatures that may encode a difference, microarrays comprising 887 human miRNAs in strictly matched early stage (I-II) pancreatic body/tail cancers and head cancers were performed and the results were further verified by qRT-PCR. We found remarkably down-regulated miR-501-3p and up-regulated miR-375 expressions in pancreatic body/tail cancer compared with head cancer. The recurrence rate was obviously lower in pancreatic body/tail cancer, and the down-regulation of miR-501-3p was significantly associated with low-risk of recurrence after curative surgery. By in vitro study, we provided first evidence that miR-501-3p could promote invasion of PDAC cells (Panc-1 and Colo357) possibly via decreasing the expression of E-Cadherin. Our results suggest that pancreatic body/tail cancer might be ‘less’ malignant than pancreatic head cancer and two miRNAs (miR-501-3p and -375) may encode this diversity. 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8-diss-131738$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/diss_mods_00013173 5051 610 5550 diversity 5550 microRNA 5550 pancreatic cancer 5550 tumor location