@PhdThesis{diss_mods_00017423, author = {Aziz, Shahir}, title = {Trehalose physicochemical characteristics as a potential dry powder inhalation carrier for optimized aerosol generation}, year = {2015}, publisher = {Christian-Albrechts-Universit{\"a}t zu Kiel}, address = {Kiel}, keywords = {Trehalose; Dry powder inhalation; Fine carrier; Oseltamivir phosphate; budesonide; Salbutamol}, abstract = {The study aims to utilize trehalose particles as an inert fine carrier to improve DPI aerosolization performance, diversify the potential delivery of new drugs in DPI formulations and the feasibility of bringing high drug dose into the lungs. Inhalable fine trehalose particles were engineered by jet milling and spray drying to reach different physicochemical characteristics that were assessed and related to the evaluated aerosolization performance of the prepared formulations with model drugs. The delivery of high dose of oseltamivir phosphate (OP) antiviral drug was further improved in formulations of 25{\%} fine trehalose particles reaching about 75{\%} fine particle fraction (FPF) as assessed by cascade impaction. The aerosol generation of model COPD inhalable drugs was evaluated on the bases of their hydrophilic and hydrophobic nature affecting their agglomeration behavior with trehalose fine particles. Accordingly, different trehalose batches presenting different physicochemical characteristics such as particle size, morphology, surface energy, crystallinity, and hydration exhibited variation in aerosolization performance from 1{\%} till 80{\%} FPF as assessed by impaction. In summary, tailored DPI formulations are essential for every active pharmaceutical ingredient and particle engineering of both the carrier and the drug control the outcome of the formulation performance. Trehalose particles have shown compatibility, stability and aerosol generation effectiveness with a variety of API types and ratios. This concludes that fine trehalose particles have the potential for being an outstanding inert and safe carrier for the delivery of new and current API in DPI formulations.}, url = {https://macau.uni-kiel.de/receive/diss_mods_00017423}, file = {:https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/dissertation_derivate_00006200/S.Aziz_-PhD-Thesis.pdf:PDF}, language = {en} }