PT Unknown AU Rieper, S TI Potential of Phytonutrients to act as Mimetics for Caloric Restriction: Identification of the Transcriptional and Functional Overlap in silico PY 2017 PU Christian-Albrechts-Universität zu Kiel WP https://macau.uni-kiel.de/receive/diss_mods_00020379 LA en DE caloric restriction; phytonutients; in silico; resveratrol; phloridzin; quercetin; genistein; calorie restriction; microarray; affy; beadarray; illumina; ArrayExpress; Gene Expression Omnibus; GEO; gene expression; Sirt1; Foxo; Igf1; mTOR; oxidative stress; lifespan; Kalorienrestriktion; sekundäre Pflanzenstoffe; Mikroarray; Genexpression; oxidativer Stress; Lebenserwartung AB Caloric restriction (CR) is known for its beneficial effects on life- and healthspan (lifespan without the occurrence of age-related diseases) in several model organisms. However, it is assumed to be very difficult for humans to sustain long-term CR. Therefore, it is of interest to identify CR mimetics that are able to enhance health- and lifespan without restriction of the calorie intake. Several promising pharmaceutical substances have been identified, but most of them show side effects like toxicity and indigestion. Therefore it would be of importance to identity food derived compounds such as plant bioactives as potential CR mimetics in silico. To that account, data of previously published gene expression studies in murine liver were used and downloaded from the databases ArrayExpress and Gene Expression Omnibus (GEO). The results of the in silico analysis show that resveratrol and quercetin are the most promising mimetics of CR by showing an overlap in gene expression and addressing similar molecules (e.g. Sirt1, Foxo) and signalling cascades (Igf1-signalling, mTOR-signalling, oxidative stress defence). PI Kiel ER