@Article{macau_mods_00000590, author = {Geritz, Johanna and Maetzold, Sara and Steffen, Maren and Pilotto, Andrea and Corr{\`a}, Marta F. and Moscovich, Mariana and Rizzetti, Maria C. and Borroni, Barbara and Padovani, Alessandro and Alpes, Annekathrin and Bang, Corinna and Barcellos, Igor and Baron, Ralf and Bartsch, Thorsten and Becktepe, Jos S. and Berg, Daniela and Bergeest, Lu M. and Bergmann, Philipp and Bou{\c{c}}a-Machado, Raquel and Drey, Michael and Elshehabi, Morad and Farahmandi, Susan and Ferreira, Joaquim J. and Franke, Andre and Friederich, Anja and Geisler, Corinna and H{\"u}llemann, Philipp and Gierthm{\"u}hlen, Janna and Granert, Oliver and Heinzel, Sebastian and Heller, Maren K. and Hobert, Markus A. and Hofmann, Marc and Jemlich, Bj{\"o}rn and Kerkmann, Laura and Kn{\"u}pfer, Stephanie and Krause, Katharina and Kress, Maximilian and Krupp, Sonja and Kudelka, Jennifer and Kuhlenb{\"a}umer, Gregor and Kurth, Roland and Leypoldt, Frank and Maetzler, Corinna and Maia, Luis F. and Moewius, Andreas and Neumann, Patricia and Niemann, Katharina and Ortlieb, Christian T. and Paschen, Steffen and Pham, Hoang Minh and Puehler, Thomas and Radloff, Franziska and Riedel, Christian and Rogalski, Marten and Sablowsky, Simone and Schanz, Elena M. and Schebesta, Linda and Schicketm{\"u}ller, Andreas and Studt, Simone and Thieves, Martina and T{\"o}nges, Lars and Ullrich, Sebastian and Urban, Peter P. and Vila-Ch{\~a}, Nuno and Wiegard, Anna and Warmerdam, Elke and Warnecke, Tobias and Wei{\ss}, Michael and Welzel, Julius and Hansen, Clint and Maetzler, Walter}, title = {Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of a quantitative observational study before and after routine clinical geriatric treatment - the ComOn-study}, journal = {BMC geriatrics}, year = {2020}, publisher = {BioMed Central}, address = {London}, number = {20}, keywords = {Balance; Body-worn sensors; Wearables; Comprehensive geriatric assessment; Executive function; Gait; Older adults; Quantitative assessment}, abstract = {Background: Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits, (ii) to investigate the interaction between both motor and cognitive deficits and (iii) to assess health status as well as treatment outcome of 1000 geriatric inpatients in hospitals of Kiel (Germany), Brescia (Italy), Porto (Portugal), Curitiba (Brazil) and Bochum (Germany). Methods: This is a prospective, explorative observational multi-center study. In addition to the comprehensive geriatric assessment, quantitative measures of reduced mobility and motor and cognitive deficits are performed before and after a a two week's inpatient stay. Components of the assessment are mobile technology-based assessments of gait, balance and transfer performance, neuropsychological tests, frailty, sarcopenia, autonomic dysfunction and sensation, and questionnaires to assess behavioral deficits, activities of daily living, quality of life, fear of falling and dysphagia. Structural MRI and an unsupervised 24/7 home assessment of mobility are performed in a subgroup of participants. The study will also investigate the minimal clinically relevant change of the investigated parameters. Diskussion: This study will help form a better understanding of symptoms and their complex interactions and treatment effects in a large geriatric cohort.}, issn = {1471-2318}, doi = {10.1186/s12877-020-1445-z}, url = {https://macau.uni-kiel.de/receive/macau_mods_00000590}, url = {https://doi.org/10.1186/s12877-020-1445-z}, file = {:https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/macau_derivate_00001616/10.1186@s12877-020-1445-z.pdf:PDF}, language = {en} }