000K  utf8
1100  $c2021
1500  eng
2050  urn:nbn:de:gbv:8:3-2021-00430-4
2051  10.3390/polym13060847
3000  Veziroglu, Salih
3010  Acil, Yahya
3010  Aktas, Oral Cenk
3010  Ayna, Mustafa
3010  Faupel, Franz
3010  Fiutowski, Jacek
3010  Gülses, Aydin
3010  Karayürek, Fatih
3010  Kohlhaas, Theresa
3010  Mishra, Yogendra Kumar
3010  Naujokat, Hendrik
3010  Saygili, Eyüp Ilker
3010  Sayin, Selin
3010  Wiltfang, Jörg
4000  Marine Algae Incorporated Polylactide Acid Patch$dNovel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation  [Veziroglu, Salih]
4209  Biodegradable collagen-based materials have been preferred as scaffolds and grafts for diverse clinical applications in density and orthopedy. Besides the advantages of using such bio-originated materials, the use of collagen matrices increases the risk of infection transmission through the cells or the tissues of the graft/scaffold. In addition, such collagen-based solutions are not counted as economically feasible approaches due to their high production cost. In recent years, incorporation of marine algae in synthetic polymers has been considered as an alternative method for preparation grafts/scaffolds since they represent abundant and cheap source of potential biopolymers. Current work aims to propose a novel composite patch prepared by blending Sargassum vulgare powders (SVP) to polylactide (PLA) as an alternative to the porcine-derived membranes. SVP-PLA composite patches were produced by using a modified solvent casting method. Following detailed material characterization to assess the cytocompatibility, human osteoblasts (HOBs) and osteosarcoma cells (SaOS-2) were seeded on neat PLA and SVP-PLA patches. MTT and BrdU assays indicated a greater cytocompatibility and higher proliferation for HOBs cultured on SVP-PLA composite than for those cultured on neat PLA. SaOS-2 cells cultured on SVP-PLA exhibited a significant decrease in cell proliferation. The composite patch described herein exhibits an antiproliferative effect against SaOS-2 cells without impairing HOBs' adhesion and proliferation.
4950  https://doi.org/10.3390/polym13060847$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2021-00430-4$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00001460
5051  600
5051  610
5550  Composite Patch
5550  Marine algae
5550  Osteoblast
5550  Sarcoma
5550  Sargassum Vulgare