000K utf8 1100 $c2021 1500 eng 2050 urn:nbn:de:gbv:8:3-2021-00430-4 2051 10.3390/polym13060847 3000 Veziroglu, Salih 3010 Acil, Yahya 3010 Aktas, Oral Cenk 3010 Ayna, Mustafa 3010 Faupel, Franz 3010 Fiutowski, Jacek 3010 Gülses, Aydin 3010 Karayürek, Fatih 3010 Kohlhaas, Theresa 3010 Mishra, Yogendra Kumar 3010 Naujokat, Hendrik 3010 Saygili, Eyüp Ilker 3010 Sayin, Selin 3010 Wiltfang, Jörg 4000 Marine Algae Incorporated Polylactide Acid Patch$dNovel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation [Veziroglu, Salih] 4209 Biodegradable collagen-based materials have been preferred as scaffolds and grafts for diverse clinical applications in density and orthopedy. Besides the advantages of using such bio-originated materials, the use of collagen matrices increases the risk of infection transmission through the cells or the tissues of the graft/scaffold. In addition, such collagen-based solutions are not counted as economically feasible approaches due to their high production cost. In recent years, incorporation of marine algae in synthetic polymers has been considered as an alternative method for preparation grafts/scaffolds since they represent abundant and cheap source of potential biopolymers. Current work aims to propose a novel composite patch prepared by blending Sargassum vulgare powders (SVP) to polylactide (PLA) as an alternative to the porcine-derived membranes. SVP-PLA composite patches were produced by using a modified solvent casting method. Following detailed material characterization to assess the cytocompatibility, human osteoblasts (HOBs) and osteosarcoma cells (SaOS-2) were seeded on neat PLA and SVP-PLA patches. MTT and BrdU assays indicated a greater cytocompatibility and higher proliferation for HOBs cultured on SVP-PLA composite than for those cultured on neat PLA. SaOS-2 cells cultured on SVP-PLA exhibited a significant decrease in cell proliferation. The composite patch described herein exhibits an antiproliferative effect against SaOS-2 cells without impairing HOBs' adhesion and proliferation. 4950 https://doi.org/10.3390/polym13060847$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2021-00430-4$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/macau_mods_00001460 5051 600 5051 610 5550 Composite Patch 5550 Marine algae 5550 Osteoblast 5550 Sarcoma 5550 Sargassum Vulgare