000K  utf8
1100  $c2021
1500  eng
2050  urn:nbn:de:gbv:8:3-2021-00571-4
2051  10.1002/hbm.25433
3000  Wesarg, Christiane
3010  Artiges, Eric
3010  Banaschewski, Tobias
3010  Barker, Gareth J
3010  Bokde, Arun L W
3010  Brühl, Rüdiger
3010  Daedelow, Laura S
3010  Desrivières, Sylvane
3010  Flor, Herta
3010  Fröhner, Juliane H
3010  Garavan, Hugh
3010  Grigis, Antoine
3010  Heinz, Andreas
3010  Hohmann, Sarah
3010  Lett, Tristram A
3010  Martinot, Jean-Luc
3010  Nees, Frauke
3010  Oei, Nicole Y L
3010  Orfanos, Dimitri Papadopoulos
3010  Poustka, Luise
3010  Quinlan, Erin Burke
3010  Schumann, Gunter
3010  Smolka, Michael N
3010  Veer, Ilya M
3010  Walter, Henrik
3010  Whelan, Robert
4000  The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults  [Wesarg, Christiane]
4209  Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p < .025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology.
4950  https://doi.org/10.1002/hbm.25433$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2021-00571-4$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00001521
5051  150
5051  610
5550  Amygdala
5550  Child Abuse
5550  Fkbp5
5550  Gene-environment Interaction
5550  Resting-state Functional Connectivity
5550  Rs1360780
5550  Salience Network