@Article{macau_mods_00002119,
  author = 	{Klapper, Wolfram
		and Hoster, Eva
		and Determann, Olaf
		and Oschlies, Ilske
		and van der Laak, Jeroen
		and Berger, Fran{\c{c}}oise
		and Bernd, Heinz Wolfram
		and Cabe{\c{c}}adas, Jos{\'e}
		and Campo, Elias
		and Cogliatti, Sergio
		and Hansmann, Martin Leo
		and Kluin, Philip M.
		and Kodet, Roman
		and Krivolapov, Yuri A.
		and Loddenkemper, Christoph
		and Stein, Harald
		and M{\"o}ller, Peter
		and Barth, Thomas E. F.
		and M{\"u}ller-Hermelink, Konrad
		and Rosenwald, Andreas
		and Ott, German
		and Pileri, Stefano
		and Ralfkiaer, Elisabeth
		and Rymkiewicz, Grzegorz
		and van Krieken, Johan H.
		and Wacker, Hans Heinrich
		and Unterhalt, Michael
		and Hiddemann, Wolfgang
		and Dreyling, Martin},
  title = 	{Ki-67 as a prognostic marker in mantle cell lymphoma---consensus guidelines of the pathology panel of the European MCL Network},
  journal = 	{Journal of hematopathology},
  year = 	{2009},
  publisher = 	{Springer Science and Business Media LLC},
  address = 	{Berlin},
  volume = 	{2},
  number = 	{2},
  pages = 	{103--111},
  abstract = 	{Mantle cell lymphoma (MCL) has a heterogeneous clinical course and is mainly an aggressive B cell non-Hodgkin lymphoma; however, there are some indolent cases The Ki-67 index, defined by the percentage of Ki-67-positive lymphoma cells on histopathological slides, has been shown to be a very powerful prognostic biomarker. The pathology panel of the European MCL Network evaluated methods to assess the Ki-67 index including stringent counting, digital image analysis, and estimation by eyeballing. Counting of 2{\thinspace}{\texttimes}{\thinspace}500 lymphoma cells is the gold standard to assess the Ki-67 index since this value has been shown to predict survival in prospective randomized trials of the European MCL Network. Estimation by eyeballing and digital image analysis showed a poor concordance with the gold standard (concordance correlation coefficients [CCC] between 0.29 and 0.61 for eyeballing and CCC of 0.24 and 0.37 for two methods of digital image analysis, respectively). Counting a reduced number of lymphoma cells (2{\thinspace}{\texttimes}{\thinspace}100 cells) showed high interobserver agreement (CCC{\thinspace}={\thinspace}0.74). Pitfalls of the Ki-67 index are discussed and guidelines and recommendations for assessing the Ki-67 index in MCL are given.},
  issn = 	{1868-9256},
  doi = 	{10.1007/s12308-009-0036-x},
  url = 	{https://macau.uni-kiel.de/receive/macau_mods_00002119},
  url = 	{https://doi.org/10.1007/s12308-009-0036-x},
  url = 	{http://www.ncbi.nlm.nih.gov/pubmed/19669190},
  file = 	{:https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/macau_derivate_00003207/Klapper2009_Article_Ki-67AsAPrognosticMarkerInMant.pdf:PDF},
  language = 	{en}
}