000K utf8 1100 $c2009 1500 eng 2050 urn:nbn:de:gbv:8:3-2021-00735-5 2051 10.1007/s12308-009-0036-x 3000 Klapper, Wolfram 3010 Barth, Thomas E F 3010 Berger, Françoise 3010 Bernd, Heinz Wolfram 3010 Cabeçadas, José 3010 Campo, Elias 3010 Cogliatti, Sergio 3010 Determann, Olaf 3010 Dreyling, Martin 3010 Hansmann, Martin Leo 3010 Hiddemann, Wolfgang 3010 Hoster, Eva 3010 Kluin, Philip M 3010 Kodet, Roman 3010 Krivolapov, Yuri A 3010 Loddenkemper, Christoph 3010 Möller, Peter 3010 Müller-Hermelink, Konrad 3010 Oschlies, Ilske 3010 Ott, German 3010 Pileri, Stefano 3010 Ralfkiaer, Elisabeth 3010 Rosenwald, Andreas 3010 Rymkiewicz, Grzegorz 3010 Stein, Harald 3010 Unterhalt, Michael 3010 van der Laak, Jeroen 3010 van Krieken, Johan H 3010 Wacker, Hans Heinrich 4000 Ki-67 as a prognostic marker in mantle cell lymphoma—consensus guidelines of the pathology panel of the European MCL Network [Klapper, Wolfram] 4209 Mantle cell lymphoma (MCL) has a heterogeneous clinical course and is mainly an aggressive B cell non-Hodgkin lymphoma; however, there are some indolent cases The Ki-67 index, defined by the percentage of Ki-67-positive lymphoma cells on histopathological slides, has been shown to be a very powerful prognostic biomarker. The pathology panel of the European MCL Network evaluated methods to assess the Ki-67 index including stringent counting, digital image analysis, and estimation by eyeballing. Counting of 2 × 500 lymphoma cells is the gold standard to assess the Ki-67 index since this value has been shown to predict survival in prospective randomized trials of the European MCL Network. Estimation by eyeballing and digital image analysis showed a poor concordance with the gold standard (concordance correlation coefficients [CCC] between 0.29 and 0.61 for eyeballing and CCC of 0.24 and 0.37 for two methods of digital image analysis, respectively). Counting a reduced number of lymphoma cells (2 × 100 cells) showed high interobserver agreement (CCC = 0.74). Pitfalls of the Ki-67 index are discussed and guidelines and recommendations for assessing the Ki-67 index in MCL are given. 4950 https://doi.org/10.1007/s12308-009-0036-x$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2021-00735-5$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/macau_mods_00002119 5051 610