000K  utf8
1100  $c2009
1500  eng
2050  urn:nbn:de:gbv:8:3-2021-00735-5
2051  10.1007/s12308-009-0036-x
3000  Klapper, Wolfram
3010  Barth, Thomas E F
3010  Berger, Françoise
3010  Bernd, Heinz Wolfram
3010  Cabeçadas, José
3010  Campo, Elias
3010  Cogliatti, Sergio
3010  Determann, Olaf
3010  Dreyling, Martin
3010  Hansmann, Martin Leo
3010  Hiddemann, Wolfgang
3010  Hoster, Eva
3010  Kluin, Philip M
3010  Kodet, Roman
3010  Krivolapov, Yuri A
3010  Loddenkemper, Christoph
3010  Möller, Peter
3010  Müller-Hermelink, Konrad
3010  Oschlies, Ilske
3010  Ott, German
3010  Pileri, Stefano
3010  Ralfkiaer, Elisabeth
3010  Rosenwald, Andreas
3010  Rymkiewicz, Grzegorz
3010  Stein, Harald
3010  Unterhalt, Michael
3010  van der Laak, Jeroen
3010  van Krieken, Johan H
3010  Wacker, Hans Heinrich
4000  Ki-67 as a prognostic marker in mantle cell lymphoma—consensus guidelines of the pathology panel of the European MCL Network  [Klapper, Wolfram]
4209  Mantle cell lymphoma (MCL) has a heterogeneous clinical course and is mainly an aggressive B cell non-Hodgkin lymphoma; however, there are some indolent cases The Ki-67 index, defined by the percentage of Ki-67-positive lymphoma cells on histopathological slides, has been shown to be a very powerful prognostic biomarker. The pathology panel of the European MCL Network evaluated methods to assess the Ki-67 index including stringent counting, digital image analysis, and estimation by eyeballing. Counting of 2 × 500 lymphoma cells is the gold standard to assess the Ki-67 index since this value has been shown to predict survival in prospective randomized trials of the European MCL Network. Estimation by eyeballing and digital image analysis showed a poor concordance with the gold standard (concordance correlation coefficients [CCC] between 0.29 and 0.61 for eyeballing and CCC of 0.24 and 0.37 for two methods of digital image analysis, respectively). Counting a reduced number of lymphoma cells (2 × 100 cells) showed high interobserver agreement (CCC = 0.74). Pitfalls of the Ki-67 index are discussed and guidelines and recommendations for assessing the Ki-67 index in MCL are given.
4950  https://doi.org/10.1007/s12308-009-0036-x$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2021-00735-5$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00002119
5051  610