000K  utf8
1100  $c2021
1500  eng
2050  urn:nbn:de:gbv:8:3-2021-00785-0
2051  10.3390/md19100542
3000  Eckert, Thomas
3010  Burg-Roderfeld, Monika
3010  Engelhard, Peter
3010  Hesse, Karsten
3010  Hudson, John W.
3010  Jährling-Butkus, Mahena
3010  Kožár, Tibor
3010  Kozarova, Anna
3010  Louton, Helen
3010  Petridis, Athanasios K.
3010  Schauer, Roland
3010  Siebert, Hans-Christian
3010  Steinmeyer, Jürgen
3010  Zhang, Ning
3010  Zhang, Ruiyan
4000  Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms †  [Eckert, Thomas]
4209  Osteoarthritis belongs to the most common joint diseases in humans and animals and shows increased incidence in older patients. The bioactivities of collagen hydrolysates, sulfated glucosamine and a special fatty acid enriched dog-food were tested in a dog patient study of 52 dogs as potential therapeutic treatment options in early osteoarthritis. Biophysical, biochemical, cell biological and molecular modeling methods support that these well-defined substances may act as effective nutraceuticals. Importantly, the applied collagen hydrolysates as well as sulfated glucosamine residues from marine organisms were strongly supported by both an animal model and molecular modeling of intermolecular interactions. Molecular modeling of predicted interaction dynamics was evaluated for the receptor proteins MMP-3 and ADAMTS-5. These proteins play a prominent role in the maintenance of cartilage health as well as innate and adapted immunity. Nutraceutical data were generated in a veterinary clinical study focusing on mobility and agility. Specifically, key clinical parameter (MMP-3 and TIMP-1) were obtained from blood probes of German shepherd dogs with early osteoarthritis symptoms fed with collagen hydrolysates. Collagen hydrolysate, a chondroprotective food supplement was examined by high resolution NMR experiments. Molecular modeling simulations were used to further characterize the interaction potency of collagen fragments and glucosamines with protein receptor structures. Potential beneficial effects of collagen hydrolysates, sulfated glycans (i.e., sulfated glucosamine from crabs and mussels) and lipids, especially, eicosapentaenoic acid (extracted from fish oil) on biochemical and physiological processes are discussed here in the context of human and veterinary medicine.
4950  https://doi.org/10.3390/md19100542$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2021-00785-0$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00002134
5051  570
5550  Adamts-5
5550  Collagen Hydrolysate
5550  Eicosapentaenoic Acid (Epa)
5550  Mmp-3
5550  Osteoarthritis
5550  Sialic acids
5550  Sulfated N-Acetyl Glucosamine