000K  utf8
1100  $c2014
1500  eng
2050  urn:nbn:de:gbv:8:3-2021-00920-1
2051  10.1159/000355523
3000  Proksch, Ehrhardt
3010  Degwert, Joachim
3010  Oesser, Steffen
3010  Schunck, Harald
3010  Segger, Dörte
3010  Zague, Vivian
4000  Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis  [Proksch, Ehrhardt]
4209  Dietary consumption of food supplements has been found to modulate skin functions and can therefore be useful in the treatment of skin aging. However, there is only a limited number of clinical studies supporting these claims. In this double-blind, placebo-controlled study, the effectiveness of the specific bioactive collagen peptide (BCP) VERISOL® on eye wrinkle formation and stimulation of procollagen I, elastin and fibrillin biosynthesis in the skin was assessed. A hundred and fourteen women aged 45-65 years were randomized to receive 2.5 g of BCP or placebo, once daily for 8 weeks, with 57 subjects being allocated to each treatment group. Skin wrinkles were objectively measured in all subjects, before starting the treatment, after 4 and 8 weeks as well as 4 weeks after the last intake (4-week regression phase). A subgroup was established for suction blister biopsies analyzing procollagen I, elastin and fibrillin at the beginning of the treatment and after 8 weeks of intake. The ingestion of the specific BCP used in this study promoted a statistically significant reduction of eye wrinkle volume (p < 0.05) in comparison to the placebo group after 4 and 8 weeks (20%) of intake. Moreover a positive long-lasting effect was observed 4 weeks after the last BCP administration (p < 0.05). Additionally, after 8 weeks of intake a statistically significantly higher content of procollagen type I (65%) and elastin (18%) in the BCP-treated volunteers compared to the placebo-treated patients was detected. For fibrillin, a 6% increase could be determined after BCP treatment compared to the placebo, but this effect failed to reach the level of statistical significance. In conclusion, our findings demonstrate that the oral intake of specific bioactive collagen peptides (Verisol®) reduced skin wrinkles and had positive effects on dermal matrix synthesis.
4950  https://doi.org/10.1159/000355523$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2021-00920-1$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00002318
5051  610
5550  Administration, Oral
5550  Aged
5550  Collagen
5550  Collagen Type I
5550  Double-Blind Method
5550  Elastin
5550  Female
5550  Fibrillins
5550  Humans
5550  Microfilament Proteins
5550  Middle Aged
5550  Peptides
5550  Skin Aging
5550  Time Factors
5550  Treatment Outcome