000K utf8 1100 $c2021 1500 eng 2050 urn:nbn:de:gbv:8:3-2022-00176-5 2051 10.3390/biom11050614 3000 Kumar, Manoj 3010 Amarowicz, Ryszard 3010 Changan, Sushil 3010 Dhumal, Sangram 3010 Hasan, Muzaffar 3010 Maheshwari, Chirag 3010 Mekhemar, Mohamed 3010 Prajapati, Uma 3010 Punia, Sneh 3010 Sasi, Minnu 3010 Satankar, Varsha 3010 Saurabh, Vivek 3010 Singh, Surinder 3010 Thakur, Mamta 3010 Tomar, Maharishi 4000 Custard Apple (Annona squamosa L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Biological Activities [Kumar, Manoj] 4209 Annona squamosa L. (custard apple) belongs to the family Annonaceae and is an important tropical fruit cultivated in the West Indies, South and Central America, Ecuador, Peru, Brazil, India, Mexico, the Bahamas, Bermuda, and Egypt. Leaves of custard apple plants have been studied for their health benefits, which are attributed to a considerable diversity of phytochemicals. These compounds include phenol-based compounds, e.g., proanthocyanidins, comprising 18 different phenolic compounds, mainly alkaloids and flavonoids. Extracts from Annona squamosa leaves (ASLs) have been studied for their biological activities, including anticancer, antidiabetic, antioxidant, antimicrobial, antiobesity, lipid-lowering, and hepatoprotective functions. In the current article, we discussed the nutritional and phytochemical diversity of ASLs. Additionally, ASL extracts were discussed with respect to their biological activities, which were established by in vivo and in vitro experiments. A survey of the literature based on the phytochemical profile and health-promoting effects of ASLs showed that they can be used as potential ingredients for the development of pharmaceutical drugs and functional foods. Although there are sufficient findings available from in vitro and in vivo investigations, clinical trials are still needed to determine the exact effects of ASL extracts on human health. 4950 https://doi.org/10.3390/biom11050614$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2022-00176-5$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/macau_mods_00002610 5051 610 5550 Alkaloids 5550 Annona 5550 Anti-Infective Agents 5550 Antioxidants 5550 Biological activities 5550 Custard Apple Leaves 5550 Flavonoids 5550 Health Promoting Effects 5550 Humans 5550 Hypoglycemic Agents 5550 Phenolic Bioactives 5550 Phenols 5550 Phytochemicals 5550 Plant Extracts 5550 Plant Leaves