000K utf8 1100 $c2021 1500 eng 2050 urn:nbn:de:gbv:8:3-2022-00290-5 2051 10.3390/antiox10111847 3000 Sasi, Minnu 3010 Alhariri, Ahmad 3010 Bangar, Sneh Punia 3010 Chandran, Deepak 3010 Changan, Sushil 3010 Dey, Abhijit 3010 Dhumal, Sangram 3010 Hasan, Muzaffar 3010 Kumar, Ashok 3010 Kumar, Manoj 3010 Kumar, Sandeep 3010 Kumari, Shweta 3010 Mekhemar, Mohamed 3010 Pandiselvam, Ravi 3010 Prajapati, Uma 3010 Prakash, Suraj 3010 Saurabh, Vivek 3010 Senapathy, Marisennayya 3010 Singh, Surinder 3010 Tak, Yamini 3010 Thapa, Sandhya 3010 Thiyagarajan, Anitha 4000 Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies [Sasi, Minnu] 4209 Garlic (Allium sativa L.) is a bulbous flowering plant belongs to the family of Amaryllidaceae and is a predominant horticultural crop originating from central Asia. Garlic and its products are chiefly used for culinary and therapeutic purposes in many countries. Bulbs of raw garlic have been investigated for their role in oral health, which are ascribed to a myriad of biologically active compounds such as alliin, allicin, methiin, S-allylcysteine (SAC), diallyl sulfide (DAS), S-ally-mercapto cysteine (SAMC), diallyl disulphide (DADS), diallyl trisulfide (DATS) and methyl allyl disulphide. A systematic review was conducted following the PRISMA statement. Scopus, PubMed, Clinicaltrials.gov, and Science direct databases were searched between 12 April 2021 to 4 September 2021. A total of 148 studies were included and the qualitative synthesis phytochemical profile of GE, biological activities, therapeutic applications of garlic extract (GE) in oral health care system, and its mechanism of action in curing various oral pathologies have been discussed. Furthermore, the safety of incorporation of GE as food supplements is also critically discussed. To conclude, GE could conceivably make a treatment recourse for patients suffering from diverse oral diseases. 4950 https://doi.org/10.3390/antiox10111847$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2022-00290-5$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/macau_mods_00002705 5051 610 5550 Antioxidant 5550 Bioactivities 5550 Garlic 5550 Oral Cancer 5550 Oral Care 5550 Oral Health 5550 Oral Pathology 5550 Phytochemicals