000K  utf8
1100  $c2022
1500  eng
2050  urn:nbn:de:gbv:8:3-2022-00494-6
2051  10.3390/ijerph19127235
3000  Wollin, Klaus-Michael
3010  Agency, On Behalf Of The Human Biomonitoring Commission Of The German Environment
3010  Apel, Petra
3010  Chovolou, Yvonni
3010  Kolossa-Gehring, Marike
3010  Pabel, Ulrike
3010  Röhl, Claudia
3010  Schettgen, Thomas
4000  Concept for the Evaluation of Carcinogenic Substances in Population-Based Human Biomonitoring  [Wollin, Klaus-Michael]
4209  The Human Biomonitoring (HBM) Commission at the German Environment Agency holds the opinion that for environmental carcinogens for which no exposure levels can be assumed and are harmless to health, health-based guidance values corresponding to the classical definition of the HBM-I or HBM-II value cannot be established. Therefore, only reference values have been derived so far for genotoxic carcinogens from exposure data of the general population or subpopulations. The concept presented here opens up the possibility of performing health risk assessments of carcinogenic substances in human biomonitoring, and thus goes decisively beyond the purely descriptive statistical reference value concept. Using the presented method, quantitative dose descriptors of internal exposure can be derived from those of external exposure, provided that sufficient toxicokinetic information is available. Dose descriptors of internal exposure then allow the simple estimate of additional lifetime cancer risks for measured biomarker concentrations or, conversely, of equivalent concentrations for selected risks, such as those considered as tolerable for the general population. HBM data of chronic exposures to genotoxic carcinogens can thus be used to assess the additional lifetime cancer risk referring to the general population and to justify and prioritize risk management measures.
4950  https://doi.org/10.3390/ijerph19127235$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2022-00494-6$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00002944
5051  610
5550  Biological Monitoring
5550  Carcinogens
5550  Carcinogens, Environmental
5550  Environmental Exposure
5550  Environmental Monitoring
5550  Environmental Pollutants
5550  Human Biomonitoring
5550  Humans
5550  Internal exposure
5550  Reference Values
5550  risk assessment
5550  Risk Assessment