000K utf8 1100 $c2022 1500 eng 2050 urn:nbn:de:gbv:8:3-2022-00494-6 2051 10.3390/ijerph19127235 3000 Wollin, Klaus-Michael 3010 Agency, On Behalf Of The Human Biomonitoring Commission Of The German Environment 3010 Apel, Petra 3010 Chovolou, Yvonni 3010 Kolossa-Gehring, Marike 3010 Pabel, Ulrike 3010 Röhl, Claudia 3010 Schettgen, Thomas 4000 Concept for the Evaluation of Carcinogenic Substances in Population-Based Human Biomonitoring [Wollin, Klaus-Michael] 4209 The Human Biomonitoring (HBM) Commission at the German Environment Agency holds the opinion that for environmental carcinogens for which no exposure levels can be assumed and are harmless to health, health-based guidance values corresponding to the classical definition of the HBM-I or HBM-II value cannot be established. Therefore, only reference values have been derived so far for genotoxic carcinogens from exposure data of the general population or subpopulations. The concept presented here opens up the possibility of performing health risk assessments of carcinogenic substances in human biomonitoring, and thus goes decisively beyond the purely descriptive statistical reference value concept. Using the presented method, quantitative dose descriptors of internal exposure can be derived from those of external exposure, provided that sufficient toxicokinetic information is available. Dose descriptors of internal exposure then allow the simple estimate of additional lifetime cancer risks for measured biomarker concentrations or, conversely, of equivalent concentrations for selected risks, such as those considered as tolerable for the general population. HBM data of chronic exposures to genotoxic carcinogens can thus be used to assess the additional lifetime cancer risk referring to the general population and to justify and prioritize risk management measures. 4950 https://doi.org/10.3390/ijerph19127235$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2022-00494-6$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/macau_mods_00002944 5051 610 5550 Biological Monitoring 5550 Carcinogens 5550 Carcinogens, Environmental 5550 Environmental Exposure 5550 Environmental Monitoring 5550 Environmental Pollutants 5550 Human Biomonitoring 5550 Humans 5550 Internal exposure 5550 Reference Values 5550 risk assessment 5550 Risk Assessment