000K  utf8
1100  $c2018
1500  eng
2050  urn:nbn:de:gbv:8:3-2022-00619-0
2051  10.3390/ijms19010223
3000  Staats, Stefanie
3010  Kowalewski, Bianca
3010  Kulling, Sabine E
3010  Rieck, Florian T
3010  Rimbach, Gerald
3010  Soukup, Sebastian T
3010  Wagner, Anika Eva
4000  Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster  [Staats, Stefanie]
4209  In this study, we tested the effect of the stilbene resveratrol on life span, body composition, locomotor activity, stress response, and the expression of genes encoding proteins centrally involved in ageing pathways in the model organism Drosophila melanogaster. Male and female w1118 D. melanogaster were fed diets based on sucrose, corn meal, and yeast. Flies either received a control diet or a diet supplemented with 500 µmol/L resveratrol. Dietary resveratrol did not affect mean, median, and maximal life span of male and female flies. Furthermore, body composition remained largely unchanged following the resveratrol supplementation. Locomotor activity, as determined by the climbing index, was not significantly different between control and resveratrol-supplemented flies. Resveratrol-fed flies did not exhibit an improved stress response towards hydrogen peroxide as compared to controls. Resveratrol did not change mRNA steady levels of antioxidant (catalase, glutathione-S-transferase, NADH dehydrogenase, glutathione peroxidase, superoxide dismutase 2) and longevity-related genes, including sirtuin 2, spargel, and I'm Not Dead Yet. Collectively, present data suggest that resveratrol does not affect life span, body composition, locomotor activity, stress response, and longevity-associated gene expression in w1118 D. melanogaster.
4950  https://doi.org/10.3390/ijms19010223$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2022-00619-0$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00003044
5051  333.7
5051  610
5550  Animals
5550  Antioxidants
5550  Body Composition
5550  Dietary Supplements
5550  Drosophila melanogaster
5550  Drosophila Proteins
5550  Female
5550  Locomotion
5550  Longevity
5550  Male
5550  Oxidative Stress
5550  Resveratrol
5550  Stilbenes