000K utf8 1100 $c2023 1500 eng 2050 urn:nbn:de:gbv:8:3-2023-00260-8 3000 Bascon-Cardozo, Karen 4000 Deciphering the historical recombination landscape of a migratory songbird, the Eurasian blackcap$hChristian-Albrechts-Universität zu Kiel [Bascon-Cardozo, Karen] 4030 Kiel$nChristian-Albrechts-Universität zu Kiel 4209 Meiotic recombination involves the exchange of genetic information between parental chromosomes generating new combinations of alleles in the offspring. Recombination is a crucial determinant for reproductive success, proper chromosomal segregation, genetic variability, adaptation rates, and influencing the efficacy of selection. The historical recombination landscape comprises all recombination events captured in DNA sequences among individuals over many generations. Recombination involves different molecular mechanisms and recombining events are not spread randomly across the genome. The placement of recombination events in most mammals is defined by the protein PRDM9, a key player in the initiation of recombination dynamics. However, some organismal groups, such as birds, have lost this protein enabling them with unique recombining properties and conferring an apparent stasis in the positioning of recombination events. However, recent studies in species lacking PRDM9 demonstrated that recombination rates differ widely across the genome and between species. The variation in recombination rates, its causes, and its impact on evolutionary and behavioural processes remain poorly understood, particularly in natural bird populations. This thesis evaluates the variation of the historical recombination landscape in the Eurasian blackcap, Sylvia atricapilla, and the interplay of recombination rate variation with specific genomic and epigenetic features at different scales: across the genome, at inter- and intraspecific levels. 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2023-00260-8$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/macau_mods_00003579 5051 570 5550 bird genome 5550 DNA methylation 5550 eurasian blackcap 5550 genomic features 5550 historical recombination 5550 population genetics