000K  utf8
1100  $c2023
1500  eng
2050  urn:nbn:de:gbv:8:3-2023-00378-0
2051  10.1111/exd.14727
3000  Ochlich, Désirée
3010  Drerup, Katharina Antonia
3010  Gläser, Regine
3010  Harder, Jürgen
3010  Rademacher, Franziska
4000  The influence of the commensal skin bacterium Staphylococcus epidermidis on the epidermal barrier and inflammation$dImplications for atopic dermatitis  [Ochlich, Désirée]
4209  The skin microbiota is a crucial component in maintaining cutaneous barrier function. Staphylococcus epidermidis is considered as a beneficial commensal member of the cutaneous microbiota promoting skin health. However, S. epidermidis is also frequently detectable in the skin of patients with the inflammatory skin disease atopic dermatitis (AD) and some studies reported a significantly higher presence of S. epidermidis in severe AD as compared to mild AD. Therefore, this study aimed to analyse the impact of S. epidermidis on the expression of cutaneous inflammatory mediators and skin barrier molecules. Various S. epidermidis skin-derived isolates activated the proinflammatory transcription factor NF-kappaB and induced expression of AD-associated proinflammatory cytokines in human primary keratinocytes and 3D skin equivalents. Skin barrier molecules such as filaggrin were downregulated by S. epidermidis. In general, AD-derived S. epidermidis strains elicited a higher response than strains derived from the skin of healthy individuals. Taken together, our results provide further evidence that the abundance of S. epidermidis in AD may trigger the inflammatory scenario associated with this disease.
4950  https://doi.org/10.1111/exd.14727$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2023-00378-0$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00003699
5051  610
5550  Atopic Dermtitis
5550  Dermatitis, Atopic
5550  Humans
5550  Inflammation
5550  Keratinocytes
5550  Keratinocytes
5550  Skin
5550  Skin Inflammation
5550  Staphylococcus epidermidis
5550  Staphylococcus epidermidis