@Article{macau_mods_00003943, author = {Titov, Igor and Rutschke, Nils and Kraft, Fabio Aldo and K{\"o}pke, Markus and Nebling, Eric and Gerken, Martina}, title = {Detection of fluorescence-labeled DNA with in-plane organic optoelectronic devices}, journal = {Biomedical optics express}, year = {2022}, publisher = {Optica Publishing Group}, address = {Washington, DC}, volume = {13}, number = {12}, pages = {6300--6316}, keywords = {single-stranded DNA (ssDNA); fluorescence; optoelectronic; F{\"o}rster resonance transfer (FRET); multiplex biomarker; measurements}, abstract = {We present a system efficiency analysis of a monolithic integrated organic optoelectronic unit for the detection of fluorescence labeled single-stranded DNA (ssDNA) for veterinary disease testing. The side-by-side integration of an organic light emitting diode (OLED) and an organic photodetector (OPD) with 0.5 mm by 0.5 mm device sizes has the potential to enable compact and low-cost fluorescence point-of-care (POC) devices for decentral multiplex biomedical testing. Here, we used two 6-FAM and BHQ1 labeled complementary ssDNA strands to form the F{\"o}rster resonance transfer (FRET) upon the hybridization of the DNA. In this work we successfully show ssDNA hybridization sensing with samples diluted in TE buffer and investigate the detection of covalently bound 6-FAM-ssDNA on a glass surface for multiplex biomarker measurements.}, issn = {2156-7085}, doi = {10.1364/BOE.475358}, url = {https://macau.uni-kiel.de/receive/macau_mods_00003943}, url = {https://doi.org/10.1364/BOE.475358}, url = {http://www.ncbi.nlm.nih.gov/pubmed/36589587}, file = {:https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/macau_derivate_00005112/boe-13-12-6300.pdf:PDF}, language = {en} }