PT Journal AU Titov, I Rutschke, N Kraft, FA Köpke, M Nebling, E Gerken, M TI Detection of fluorescence-labeled DNA with in-plane organic optoelectronic devices SO Biomedical optics express PY 2022 BP 6300 EP 6316 VL 13 IS 12 PU Optica Publishing Group DI 10.1364/BOE.475358 WP https://macau.uni-kiel.de/receive/macau_mods_00003943 LA en DE single-stranded DNA (ssDNA); fluorescence; optoelectronic; Förster resonance transfer (FRET); multiplex biomarker; measurements SN 2156-7085 AB We present a system efficiency analysis of a monolithic integrated organic optoelectronic unit for the detection of fluorescence labeled single-stranded DNA (ssDNA) for veterinary disease testing. The side-by-side integration of an organic light emitting diode (OLED) and an organic photodetector (OPD) with 0.5 mm by 0.5 mm device sizes has the potential to enable compact and low-cost fluorescence point-of-care (POC) devices for decentral multiplex biomedical testing. Here, we used two 6-FAM and BHQ1 labeled complementary ssDNA strands to form the Förster resonance transfer (FRET) upon the hybridization of the DNA. In this work we successfully show ssDNA hybridization sensing with samples diluted in TE buffer and investigate the detection of covalently bound 6-FAM-ssDNA on a glass surface for multiplex biomarker measurements. PI Washington, DC ER