000K utf8 1100 $c2024 1500 eng 2050 urn:nbn:de:gbv:8:3-2024-00249-5 3000 Shah, Saumil Atulkumar 4000 Translational oncology: bringing theory and clinic one step closer$dBlackboard to bench, and back$hChristian-Albrechts-Universität zu Kiel [Shah, Saumil Atulkumar] 4030 Kiel$nChristian-Albrechts-Universität zu Kiel 4209 In over two centuries of cancer research, we have gone from knowing its cellular origin to knowing that it can be viewed as a rogue organ that can recruit immune cells and other healthy cells. While laboratory and clinical observations accumulate rapidly, the theory that could connect all the observations requires catching up and validation. Consequently, we have seen one-off successes in hematological malignancies, but theoretical and quantitative support is necessary to treat solid tumors. In this thesis, I present my contribution to tools in accelerating research from conceptual to laboratory and clinical phases. Each chapter in this thesis focuses on a particular characteristic of cancer cells while working with tumors of different organs. I distill the critical processes within and surrounding the tumor cells to gain mechanistic underpinnings and quantify population-level dynamics. I use ordinary differential equations and agent-based models to capture tumor cell heterogeneity and Bayesian inference to perform model selection from experimental data. The thesis aims for mechanistic insights into carcinogenesis and cancer treatment with quantitative models highlighting their value for integrative cancer research. This work explores several cancer systems unified by questions in the ecology and treatment dynamics of heterogeneous tumors. The approaches used in this work show new ways to accelerate blackboard-to-bench translation in cancer research. 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2024-00249-5$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/macau_mods_00004531 5051 500 5550 cancer 5550 CAR 5550 chemotherapy 5550 computational 5550 identifiability 5550 mathematical 5550 oncology 5550 plasticity 5550 translational 5550 treatment