000K  utf8
1100  $c2022
1500  eng
2050  urn:nbn:de:gbv:8:3-2024-00482-3
2051  10.3390/ijms231710077
3000  Şen, Sinan
3010  Erber, Ralf
4000  Neuronal Guidance Molecules in Bone Remodeling and Orthodontic Tooth Movement$hMDPI AG  [Şen, Sinan]
4030  $nMDPI AG
4209  During orthodontic tooth movement, mechanically induced remodeling occurs in the alveolar bone due to the action of orthodontic forces. The number of factors identified to be involved in mechanically induced bone remodeling is growing steadily. With the uncovering of the functions of neuronal guidance molecules (NGMs) for skeletal development as well as for bone homeostasis, NGMs are now also among the potentially significant factors for the regulation of bone remodeling during orthodontic tooth movement. This narrative review attempts to summarize the functions of NGMs in bone homeostasis and provides insight into the currently sparse literature on the functions of these molecules during orthodontic tooth movement. Presently, four families of NGMs are known: Netrins, Slits, Semaphorins, ephrins and Eph receptors. A search of electronic databases revealed roles in bone homeostasis for representatives from all four NGM families. Functions during orthodontic tooth movement, however, were only identified for Semaphorins, ephrins and Eph receptors. For these, crucial prerequisites for participation in the regulation of orthodontically induced bone remodeling, such as expression in cells of the periodontal ligament and in the alveolar bone, as well as mechanical inducibility, were shown, which suggests that the importance of NGMs in orthodontic tooth movement may be underappreciated to date and further research might be warranted.
4950  https://doi.org/10.3390/ijms231710077$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2024-00482-3$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00004767
5051  610
5550  Axon Guidance
5550  Bone Remodeling
5550  Bone Remodeling
5550  Eph receptors
5550  Ephrins
5550  Ephrins
5550  Neuronal Guidance Molecules
5550  Orthodontic Tooth Movement
5550  Periodontal Ligament
5550  Receptors, Eph Family
5550  Semaphorins
5550  Semaphorins
5550  Tooth Movement Techniques