@Article{macau_mods_00004811, author = {Rose, Ruben and Neumann, Franziska and M{\"u}ller, Sina and B{\"a}umler, Carina and Sch{\"a}fer, Miriam and Sch{\"o}n, Frieda and R{\"o}mpke, Janine and Schulze, Simone and Weyer, Dirk and Grobe, Olaf and Lorentz, Thomas and Fickenscher, Helmut and Krumbholz, Andi}, title = {Delta or Omicron BA.1/2-neutralizing antibody levels and T-cell reactivity after triple-vaccination or infection}, journal = {Allergy}, year = {2022}, publisher = {Wiley}, address = {Oxford; Copenhagen}, volume = {77}, number = {10}, pages = {3130--3133}, keywords = {T-Lymphocytes; Humans; Antibodies, Viral; Vaccination; Antibodies, Neutralizing}, abstract = {In Germany, SARS-CoV-2 infections in fall 2021 were caused by the Delta (B.1.617.2) variant of concern (VOC), which was completely replaced by the Omicron (BA.1, B.1.529.1/BA.2, B.1.529.2) VOC in winter. Meanwhile, the BA.2 sublineage dominates, apparently having a selection advantage. We studied the kinetics of anti-spike (S) protein IgG, Delta neutralizing antibodies (NA), and the release of interferon-gamma (IFN-$\gamma$) from stimulated T-cells in 152 individuals (117/35 women/men, median age 41{\thinspace}years) who received two doses of vector vaccine (AstraZeneca, AZD, N = 34), mRNA vaccine (BioNTech/Moderna, mRNA, N = 62), or a combination of both (N = 56) followed by an mRNA vaccine booster (N = 81). Delta and Omicron BA.1/BA.2 NAs and T-cell reactivity were analyzed in a subset of 15 age- and gender-matched vaccinees and in 10 triple-vaccinated and two unvaccinated individuals after BA.1 infection. The presence of Delta and Omicron BA.1-NA was assessed in unvaccinated convalescents after Alpha (N = 10) or Beta (N = 1) VOC infection. For more information, see the Appendix S1.}, issn = {0105-4538}, doi = {10.1111/all.15395}, url = {https://macau.uni-kiel.de/receive/macau_mods_00004811}, url = {https://doi.org/10.1111/all.15395}, url = {http://www.ncbi.nlm.nih.gov/pubmed/35652740}, file = {:https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/macau_derivate_00006100/Allergy%20-%202022%20-%20Rose%20-%20Delta%20or%20Omicron%20BA%201%202‐neutralizing%20antibody%20levels%20and%20T‐cell%20reactivity%20after%20triple‐vaccination.pdf:PDF}, language = {en} }