PT Journal
AU Rose, R
   Neumann, F
   Müller, S
   Bäumler, C
   Schäfer, M
   Schön, F
   Römpke, J
   Schulze, S
   Weyer, D
   Grobe, O
   Lorentz, T
   Fickenscher, H
   Krumbholz, A
TI Delta or Omicron BA.1/2-neutralizing antibody levels and T-cell reactivity after triple-vaccination or infection
SO Allergy
JI Allergy
PY 2022
BP 3130
EP 3133
VL 77
IS 10
PU Wiley
DI 10.1111/all.15395
WP https://macau.uni-kiel.de/receive/macau_mods_00004811
LA en
DE T-Lymphocytes; Humans; Antibodies, Viral; Vaccination; Antibodies, Neutralizing
SN 0105-4538
AB In Germany, SARS-CoV-2 infections in fall 2021 were caused by the Delta (B.1.617.2) variant of concern (VOC), which was completely replaced by the Omicron (BA.1, B.1.529.1/BA.2, B.1.529.2) VOC in winter. Meanwhile, the BA.2 sublineage dominates, apparently having a selection advantage. We studied the kinetics of anti-spike (S) protein IgG, Delta neutralizing antibodies (NA), and the release of interferon-gamma (IFN-γ) from stimulated T-cells in 152 individuals (117/35 women/men, median age 41 years) who received two doses of vector vaccine (AstraZeneca, AZD, N = 34), mRNA vaccine (BioNTech/Moderna, mRNA, N = 62), or a combination of both (N = 56) followed by an mRNA vaccine booster (N = 81). Delta and Omicron BA.1/BA.2 NAs and T-cell reactivity were analyzed in a subset of 15 age- and gender-matched vaccinees and in 10 triple-vaccinated and two unvaccinated individuals after BA.1 infection. The presence of Delta and Omicron BA.1-NA was assessed in unvaccinated convalescents after Alpha (N = 10) or Beta (N = 1) VOC infection. For more information, see the Appendix S1.
PI Oxford; Copenhagen
ER