000K  utf8
1100  $c2022
1500  eng
2050  urn:nbn:de:gbv:8:3-2024-00526-8
2051  10.1111/all.15395
3000  Rose, Ruben
3010  Bäumler, Carina
3010  Fickenscher, Helmut
3010  Grobe, Olaf
3010  Krumbholz, Andi
3010  Lorentz, Thomas
3010  Müller, Sina
3010  Neumann, Franziska
3010  Römpke, Janine
3010  Schäfer, Miriam
3010  Schön, Frieda
3010  Schulze, Simone
3010  Weyer, Dirk
4000  Delta or Omicron BA.1/2-neutralizing antibody levels and T-cell reactivity after triple-vaccination or infection$hWiley  [Rose, Ruben]
4030  $nWiley
4209  In Germany, SARS-CoV-2 infections in fall 2021 were caused by the Delta (B.1.617.2) variant of concern (VOC), which was completely replaced by the Omicron (BA.1, B.1.529.1/BA.2, B.1.529.2) VOC in winter. Meanwhile, the BA.2 sublineage dominates, apparently having a selection advantage. We studied the kinetics of anti-spike (S) protein IgG, Delta neutralizing antibodies (NA), and the release of interferon-gamma (IFN-γ) from stimulated T-cells in 152 individuals (117/35 women/men, median age 41 years) who received two doses of vector vaccine (AstraZeneca, AZD, N = 34), mRNA vaccine (BioNTech/Moderna, mRNA, N = 62), or a combination of both (N = 56) followed by an mRNA vaccine booster (N = 81). Delta and Omicron BA.1/BA.2 NAs and T-cell reactivity were analyzed in a subset of 15 age- and gender-matched vaccinees and in 10 triple-vaccinated and two unvaccinated individuals after BA.1 infection. The presence of Delta and Omicron BA.1-NA was assessed in unvaccinated convalescents after Alpha (N = 10) or Beta (N = 1) VOC infection. For more information, see the Appendix S1.
4950  https://doi.org/10.1111/all.15395$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2024-00526-8$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00004811
5051  610
5550  Antibodies, Neutralizing
5550  Antibodies, Viral
5550  Humans
5550  T-Lymphocytes
5550  Vaccination