000K utf8 1100 $c2022 1500 eng 2050 urn:nbn:de:gbv:8:3-2024-00526-8 2051 10.1111/all.15395 3000 Rose, Ruben 3010 Bäumler, Carina 3010 Fickenscher, Helmut 3010 Grobe, Olaf 3010 Krumbholz, Andi 3010 Lorentz, Thomas 3010 Müller, Sina 3010 Neumann, Franziska 3010 Römpke, Janine 3010 Schäfer, Miriam 3010 Schön, Frieda 3010 Schulze, Simone 3010 Weyer, Dirk 4000 Delta or Omicron BA.1/2-neutralizing antibody levels and T-cell reactivity after triple-vaccination or infection$hWiley [Rose, Ruben] 4030 $nWiley 4209 In Germany, SARS-CoV-2 infections in fall 2021 were caused by the Delta (B.1.617.2) variant of concern (VOC), which was completely replaced by the Omicron (BA.1, B.1.529.1/BA.2, B.1.529.2) VOC in winter. Meanwhile, the BA.2 sublineage dominates, apparently having a selection advantage. We studied the kinetics of anti-spike (S) protein IgG, Delta neutralizing antibodies (NA), and the release of interferon-gamma (IFN-γ) from stimulated T-cells in 152 individuals (117/35 women/men, median age 41 years) who received two doses of vector vaccine (AstraZeneca, AZD, N = 34), mRNA vaccine (BioNTech/Moderna, mRNA, N = 62), or a combination of both (N = 56) followed by an mRNA vaccine booster (N = 81). Delta and Omicron BA.1/BA.2 NAs and T-cell reactivity were analyzed in a subset of 15 age- and gender-matched vaccinees and in 10 triple-vaccinated and two unvaccinated individuals after BA.1 infection. The presence of Delta and Omicron BA.1-NA was assessed in unvaccinated convalescents after Alpha (N = 10) or Beta (N = 1) VOC infection. For more information, see the Appendix S1. 4950 https://doi.org/10.1111/all.15395$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2024-00526-8$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/macau_mods_00004811 5051 610 5550 Antibodies, Neutralizing 5550 Antibodies, Viral 5550 Humans 5550 T-Lymphocytes 5550 Vaccination