PT Journal
AU Pauli, P
   Goetz, K
   Rogge, A
   Bartsch, T
   Philippen, S
   Berg, DDD
   Hertrampf, K
TI Attitudes and Viewpoints Toward Prevention Trials in Alzheimer’s Disease
SO GeroPsych : the journal of gerontopsychology and geriatric psychiatry
JI GeroPsych
PY 2024
BP 102
EP 108
VL 37
IS 2
PU Hogrefe Publishing Group
DI 10.1024/1662-9647/a000311
WP https://macau.uni-kiel.de/receive/macau_mods_00005553
LA en
DE Alzheimer’s disease; prevention studies; barriers; qualitative study; risk disclosure
SN 1662-9647
AB Alzheimer’s disease (AD) prevention studies use biomarkers to determine risk in asymptomatic study participants. This involves multifaceted implications. Determinants regarding participation in these trials are therefore of particular relevance. We used semistructured individual interviews to interview uninvolved persons (n = 10), relatives of Alzheimer’s patients (n = 10), and patients with mild cognitive impairment (n = 5) and analyzed the interviews using qualitative content analysis according to Mayring. We discovered various factors to be positive motivations for participation; the most significant inhibiting factor was concern about negative psychological effects. These motivations and concerns should be specifically addressed in the study design of AD prevention trials. The fears and concerns expressed highlight the importance of a good methodological and ethical framework to increase participant acceptance.
PI Bern
ER