PT Journal AU Pauli, P Goetz, K Rogge, A Bartsch, T Philippen, S Berg, DDD Hertrampf, K TI Attitudes and Viewpoints Toward Prevention Trials in Alzheimer’s Disease SO GeroPsych : the journal of gerontopsychology and geriatric psychiatry JI GeroPsych PY 2024 BP 102 EP 108 VL 37 IS 2 PU Hogrefe Publishing Group DI 10.1024/1662-9647/a000311 WP https://macau.uni-kiel.de/receive/macau_mods_00005553 LA en DE Alzheimer’s disease; prevention studies; barriers; qualitative study; risk disclosure SN 1662-9647 AB Alzheimer’s disease (AD) prevention studies use biomarkers to determine risk in asymptomatic study participants. This involves multifaceted implications. Determinants regarding participation in these trials are therefore of particular relevance. We used semistructured individual interviews to interview uninvolved persons (n = 10), relatives of Alzheimer’s patients (n = 10), and patients with mild cognitive impairment (n = 5) and analyzed the interviews using qualitative content analysis according to Mayring. We discovered various factors to be positive motivations for participation; the most significant inhibiting factor was concern about negative psychological effects. These motivations and concerns should be specifically addressed in the study design of AD prevention trials. The fears and concerns expressed highlight the importance of a good methodological and ethical framework to increase participant acceptance. PI Bern ER