PT Journal
AU Grund, J
   Iben, K
   Reinke, S
   Bühnen, I
   Plütschow, A
   Müller-Meinhard, B
   Garcia Marquez, MA
   Schlößer, HA
   von Tresckow, B
   Kellermeier, F
   Borchmann, P
   Engert, A
   Bröckelmann, PJ
   Klapper, W
TI Low B‐cell content is associated with a CD73 ‐low tumour microenvironment and unfavourable prognosis in classic Hodgkin lymphoma
SO British journal of haematology : BJHaem : an official journal of the British Society for Haematology / ed. R. B. Thompson [u.a.]
JI Br J Haematol
PY 2023
BP 1097
EP 1102
VL 201
IS 6
PU Wiley
DI 10.1111/bjh.18762
WP https://macau.uni-kiel.de/receive/macau_mods_00005585
LA en
DE Humans; Hodgkin Disease; Dacarbazine; Vinblastine; Doxorubicin; Bleomycin; Antineoplastic Combined Chemotherapy Protocols; Prognosis; Prospective Studies; Tumor Microenvironment; Microenvironment; B-cells; Hodgkins Lymphoma
SN 0007-1048
AB B-cell content in the tumour microenvironment (TME) of classic Hodgkin lymphoma (HL) is known to be associated with prognosis. Here we demonstrate that whole slide image analysis using routinely available slides predicts outcomes in patients treated with ABVD in a prospective trial with a high B-cell content being associated with a favourable prognosis. B cells in the TME did not correlate with B cells in peripheral blood. In the TME maturation, stages of B cells (naive and memory) were consistent. However, we detected down-regulation of CD73 in HL with low B cells suggestive of an antibody-independent function of B cells in the TME of HL.
PI Oxford [u.a.]
ER