000K  utf8
1100  $c2023
1500  eng
2050  urn:nbn:de:gbv:8:3-2025-00064-8
2051  10.1111/bjh.18762
3000  Grund, Johanna
3010  Borchmann, Peter
3010  Bröckelmann, Paul J
3010  Bühnen, Ina
3010  Engert, Andreas
3010  Garcia Marquez, Maria A
3010  Iben, Katharina
3010  Kellermeier, Fabian
3010  Klapper, Wolfram
3010  Müller-Meinhard, Berit
3010  Plütschow, Annette
3010  Reinke, Sarah
3010  Schlößer, Hans A
3010  von Tresckow, Bastian
4000  Low B‐cell content is associated with a CD73 ‐low tumour microenvironment and unfavourable prognosis in classic Hodgkin lymphoma$hWiley  [Grund, Johanna]
4030  $nWiley
4209  B-cell content in the tumour microenvironment (TME) of classic Hodgkin lymphoma (HL) is known to be associated with prognosis. Here we demonstrate that whole slide image analysis using routinely available slides predicts outcomes in patients treated with ABVD in a prospective trial with a high B-cell content being associated with a favourable prognosis. B cells in the TME did not correlate with B cells in peripheral blood. In the TME maturation, stages of B cells (naive and memory) were consistent. However, we detected down-regulation of CD73 in HL with low B cells suggestive of an antibody-independent function of B cells in the TME of HL.
4950  https://doi.org/10.1111/bjh.18762$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2025-00064-8$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00005585
5051  610
5550  Antineoplastic Combined Chemotherapy Protocols
5550  B-cells
5550  Bleomycin
5550  Dacarbazine
5550  Doxorubicin
5550  Hodgkin Disease
5550  Hodgkins Lymphoma
5550  Humans
5550  Microenvironment
5550  Prognosis
5550  Prospective Studies
5550  Tumor Microenvironment
5550  Vinblastine