000K utf8 1100 $c2023 1500 eng 2050 urn:nbn:de:gbv:8:3-2025-00064-8 2051 10.1111/bjh.18762 3000 Grund, Johanna 3010 Borchmann, Peter 3010 Bröckelmann, Paul J 3010 Bühnen, Ina 3010 Engert, Andreas 3010 Garcia Marquez, Maria A 3010 Iben, Katharina 3010 Kellermeier, Fabian 3010 Klapper, Wolfram 3010 Müller-Meinhard, Berit 3010 Plütschow, Annette 3010 Reinke, Sarah 3010 Schlößer, Hans A 3010 von Tresckow, Bastian 4000 Low B‐cell content is associated with a CD73 ‐low tumour microenvironment and unfavourable prognosis in classic Hodgkin lymphoma$hWiley [Grund, Johanna] 4030 $nWiley 4209 B-cell content in the tumour microenvironment (TME) of classic Hodgkin lymphoma (HL) is known to be associated with prognosis. Here we demonstrate that whole slide image analysis using routinely available slides predicts outcomes in patients treated with ABVD in a prospective trial with a high B-cell content being associated with a favourable prognosis. B cells in the TME did not correlate with B cells in peripheral blood. In the TME maturation, stages of B cells (naive and memory) were consistent. However, we detected down-regulation of CD73 in HL with low B cells suggestive of an antibody-independent function of B cells in the TME of HL. 4950 https://doi.org/10.1111/bjh.18762$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2025-00064-8$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/macau_mods_00005585 5051 610 5550 Antineoplastic Combined Chemotherapy Protocols 5550 B-cells 5550 Bleomycin 5550 Dacarbazine 5550 Doxorubicin 5550 Hodgkin Disease 5550 Hodgkins Lymphoma 5550 Humans 5550 Microenvironment 5550 Prognosis 5550 Prospective Studies 5550 Tumor Microenvironment 5550 Vinblastine