PT Journal AU Suhrkamp, I Scheffold, GA Heine, AG TI T-cell subsets in allergy and tolerance induction SO European journal of immunology JI Eur J Immunol PY 2023 BP e2249983 VL 53 IS 10 PU Wiley DI 10.1002/eji.202249983 WP https://macau.uni-kiel.de/receive/macau_mods_00005587 LA en DE T-Lymphocyte Subsets; Humans; Hypersensitivity; Allergens; Desensitization, Immunologic; Immune Tolerance; T-Lymphocytes, Regulatory; Allergy; T cells; Allergen Immunotherapy; Th2a; Tfh13 SN 0014-2980 AB Antigen-specific T lymphocytes are the central regulators of tolerance versus immune pathology against otherwise innocuous antigens and key targets of antigen-specific immune therapy. Recent advances in the understanding of T cells in tolerance and allergy resulted from improved technologies to directly characterize allergen-specific T cells by multiparameter flow cytometry or single-cell sequencing. This unravelled phenotypically and functionally distinct populations, such as Type 2a T helper cells (Th2a), follicular Th cells (Tfh), regulatory T cells (Treg), Type 1 regulatory T cells (Tr1), and follicular T regulatory cells. Here we will discuss the role of the different Th-cell subsets in the healthy state, during sensitization and development of allergy, and in tolerance induction by allergen immunotherapy (AIT). To date, the mechanisms of AIT as the only causal treatment of allergy are not completely understood. The analyses of allergen-specific T cells directly ex vivo during AIT support the concept of specific-Th2(a) cell deletion rather than an expansion of allergen-specific Tr1 or Treg cells as underlying mechanism. PI Weinheim; Weinheim, Bergstr.; [Weinheim] ER