000K utf8 1100 $c2023 1500 eng 2050 urn:nbn:de:gbv:8:3-2025-00066-8 2051 10.1002/eji.202249983 3000 Suhrkamp, Ina 3010 Heine, Arndt Guido 3010 Scheffold, Georg Alexander 4000 T-cell subsets in allergy and tolerance induction$hWiley [Suhrkamp, Ina] 4030 $nWiley 4209 Antigen-specific T lymphocytes are the central regulators of tolerance versus immune pathology against otherwise innocuous antigens and key targets of antigen-specific immune therapy. Recent advances in the understanding of T cells in tolerance and allergy resulted from improved technologies to directly characterize allergen-specific T cells by multiparameter flow cytometry or single-cell sequencing. This unravelled phenotypically and functionally distinct populations, such as Type 2a T helper cells (Th2a), follicular Th cells (Tfh), regulatory T cells (Treg), Type 1 regulatory T cells (Tr1), and follicular T regulatory cells. Here we will discuss the role of the different Th-cell subsets in the healthy state, during sensitization and development of allergy, and in tolerance induction by allergen immunotherapy (AIT). To date, the mechanisms of AIT as the only causal treatment of allergy are not completely understood. The analyses of allergen-specific T cells directly ex vivo during AIT support the concept of specific-Th2(a) cell deletion rather than an expansion of allergen-specific Tr1 or Treg cells as underlying mechanism. 4950 https://doi.org/10.1002/eji.202249983$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2025-00066-8$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/macau_mods_00005587 5051 610 5550 Allergen Immunotherapy 5550 Allergens 5550 Allergy 5550 Desensitization, Immunologic 5550 Humans 5550 Hypersensitivity 5550 Immune Tolerance 5550 T cells 5550 Tfh13 5550 Th2a 5550 T-Lymphocytes, Regulatory 5550 T-Lymphocyte Subsets