000K  utf8
1100  $c2023
1500  eng
2050  urn:nbn:de:gbv:8:3-2025-00066-8
2051  10.1002/eji.202249983
3000  Suhrkamp, Ina
3010  Heine, Arndt Guido
3010  Scheffold, Georg Alexander
4000  T-cell subsets in allergy and tolerance induction$hWiley  [Suhrkamp, Ina]
4030  $nWiley
4209  Antigen-specific T lymphocytes are the central regulators of tolerance versus immune pathology against otherwise innocuous antigens and key targets of antigen-specific immune therapy. Recent advances in the understanding of T cells in tolerance and allergy resulted from improved technologies to directly characterize allergen-specific T cells by multiparameter flow cytometry or single-cell sequencing. This unravelled phenotypically and functionally distinct populations, such as Type 2a T helper cells (Th2a), follicular Th cells (Tfh), regulatory T cells (Treg), Type 1 regulatory T cells (Tr1), and follicular T regulatory cells. Here we will discuss the role of the different Th-cell subsets in the healthy state, during sensitization and development of allergy, and in tolerance induction by allergen immunotherapy (AIT). To date, the mechanisms of AIT as the only causal treatment of allergy are not completely understood. The analyses of allergen-specific T cells directly ex vivo during AIT support the concept of specific-Th2(a) cell deletion rather than an expansion of allergen-specific Tr1 or Treg cells as underlying mechanism.
4950  https://doi.org/10.1002/eji.202249983$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2025-00066-8$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00005587
5051  610
5550  Allergen Immunotherapy
5550  Allergens
5550  Allergy
5550  Desensitization, Immunologic
5550  Humans
5550  Hypersensitivity
5550  Immune Tolerance
5550  T cells
5550  Tfh13
5550  Th2a
5550  T-Lymphocytes, Regulatory
5550  T-Lymphocyte Subsets