PT Journal
AU Lütgendorf-Caucig, C
   Wieland, P
   Hug, E
   Flechl, B
   Tubin, S
   Galalae, R
   Georg, P
   Fossati, P
   Mumot, M
   Harrabi, S
   Pradler, I
   Pelak, MJ
TI The Value of PET/CT in Particle Therapy Planning of Various Tumors with SSTR2 Receptor Expression: Comparative Interobserver Study
SO Cancers
JI Cancers
PY 2024
BP 1877
VL 16
IS 10
PU MDPI AG
DI 10.3390/cancers16101877
WP https://macau.uni-kiel.de/receive/macau_mods_00005900
LA en
DE Meningioma; Pet/ct; Dota; Proton Therapy; Contouring; Interobserver Variability; Pitnet; Glomus Tympanicum Tumor
SN 2072-6694
AB The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including 30 meningiomas, 12 PitNET and 5 SBPGL. Four independent observers were instructed to contour the macroscopic tumor volume on planning MRI and then reassess their volumes with the additional information from DOTA-PET/CT. The conformity between observers and reference volumes was assessed. In total, 46 cases (97.9%) were DOTA-avid and included in the final analysis. In eight cases, PET/CT additional tumor volume was identified that was not detected by MRI; these PET/CT findings were potentially critical for the treatment plan in four cases. For meningiomas, the interobserver and observer to reference volume conformity indices were higher with PET/CT. For PitNET, the volumes had higher conformity between observers with MRI. With regard to SBGDL, no significant trend towards conformity with the addition of PET/CT information was observed. DOTA PET/CT supports accurate tumor recognition in meningioma and PitNET and is recommended in SSTR2-expressing tumors planned for treatment with highly conformal radiation.
PI Basel
ER