000K  utf8
1100  $c2024
1500  eng
2050  urn:nbn:de:gbv:8:3-2025-00369-4
2051  10.3390/cancers16101877
3000  Lütgendorf-Caucig, Carola
3010  Flechl, Birgit
3010  Fossati, Piero
3010  Galalae, Razvan
3010  Georg, Petra
3010  Harrabi, Semi
3010  Hug, Eugen
3010  Mumot, Marta
3010  Pelak, Maciej J
3010  Pradler, Irina
3010  Tubin, Slavisa
3010  Wieland, Patricia
4000  The Value of PET/CT in Particle Therapy Planning of Various Tumors with SSTR2 Receptor Expression: Comparative Interobserver Study$hMDPI AG  [Lütgendorf-Caucig, Carola]
4030  $nMDPI AG
4209  The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including 30 meningiomas, 12 PitNET and 5 SBPGL. Four independent observers were instructed to contour the macroscopic tumor volume on planning MRI and then reassess their volumes with the additional information from DOTA-PET/CT. The conformity between observers and reference volumes was assessed. In total, 46 cases (97.9%) were DOTA-avid and included in the final analysis. In eight cases, PET/CT additional tumor volume was identified that was not detected by MRI; these PET/CT findings were potentially critical for the treatment plan in four cases. For meningiomas, the interobserver and observer to reference volume conformity indices were higher with PET/CT. For PitNET, the volumes had higher conformity between observers with MRI. With regard to SBGDL, no significant trend towards conformity with the addition of PET/CT information was observed. DOTA PET/CT supports accurate tumor recognition in meningioma and PitNET and is recommended in SSTR2-expressing tumors planned for treatment with highly conformal radiation.
4950  https://doi.org/10.3390/cancers16101877$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2025-00369-4$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/macau_mods_00005900
5051  610
5550  Contouring
5550  Dota
5550  Glomus Tympanicum Tumor
5550  Interobserver Variability
5550  Meningioma
5550  Pet/ct
5550  Pitnet
5550  Proton Therapy