000K utf8 1100 $c2024 1500 eng 2050 urn:nbn:de:gbv:8:3-2025-00369-4 2051 10.3390/cancers16101877 3000 Lütgendorf-Caucig, Carola 3010 Flechl, Birgit 3010 Fossati, Piero 3010 Galalae, Razvan 3010 Georg, Petra 3010 Harrabi, Semi 3010 Hug, Eugen 3010 Mumot, Marta 3010 Pelak, Maciej J 3010 Pradler, Irina 3010 Tubin, Slavisa 3010 Wieland, Patricia 4000 The Value of PET/CT in Particle Therapy Planning of Various Tumors with SSTR2 Receptor Expression: Comparative Interobserver Study$hMDPI AG [Lütgendorf-Caucig, Carola] 4030 $nMDPI AG 4209 The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including 30 meningiomas, 12 PitNET and 5 SBPGL. Four independent observers were instructed to contour the macroscopic tumor volume on planning MRI and then reassess their volumes with the additional information from DOTA-PET/CT. The conformity between observers and reference volumes was assessed. In total, 46 cases (97.9%) were DOTA-avid and included in the final analysis. In eight cases, PET/CT additional tumor volume was identified that was not detected by MRI; these PET/CT findings were potentially critical for the treatment plan in four cases. For meningiomas, the interobserver and observer to reference volume conformity indices were higher with PET/CT. For PitNET, the volumes had higher conformity between observers with MRI. With regard to SBGDL, no significant trend towards conformity with the addition of PET/CT information was observed. DOTA PET/CT supports accurate tumor recognition in meningioma and PitNET and is recommended in SSTR2-expressing tumors planned for treatment with highly conformal radiation. 4950 https://doi.org/10.3390/cancers16101877$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:8:3-2025-00369-4$xR$3Volltext$534 4961 https://macau.uni-kiel.de/receive/macau_mods_00005900 5051 610 5550 Contouring 5550 Dota 5550 Glomus Tympanicum Tumor 5550 Interobserver Variability 5550 Meningioma 5550 Pet/ct 5550 Pitnet 5550 Proton Therapy