Refining the genetic signature of bacterial genotoxin colibactin and its presence in premalignant lesions of colorectal cancer

This work not only defines how colibactin leaves a lasting mutational signature in human cells but also establishes SBS88 as a functional and clinically relevant biomarker of microbial genotoxicity. By integrating microbiology, cancer genomics, and regenerative biology, it contributes to a broader effort to translate mutational signatures into mechanistic insight, prevention strategies, and precision medicine for colorectal cancer.

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