000K  utf8
1100  $c2016
1500  eng
2050  urn:nbn:de:gbv:8-publ-24249
2051  10.3389/fnagi.2016.00121
3000  Lerche, Stefanie
3010  Alves, Guido W.
3010  Barone, Paolo
3010  Behnke, Stefanie
3010  Ben-Shlomo, Yoav
3010  Berendse, Henk
3010  Berg, Daniela Dagmar Denise
3010  Bloem, Bastiaan R.
3010  Burn, David
3010  Dodel, Richard
3010  Grosset, Donald G.
3010  Heinzel, Sebastian
3010  Hipp, Geraldine
3010  Hu, Michele T.
3010  Kasten, Meike
3010  Krüger, Rejko
3010  Liepelt-Scarfone, Inga
3010  Mätzler, Walter
3010  Moccia, Marcello
3010  Mollenhauer, Brit
3010  Oertel, Wolfgang
3010  Roeben, Benjamin
3010  Walter, Uwe
3010  Wirdefeldt, Karin
4000  Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies  [Lerche, Stefanie]
4209  Parkinson’s disease (PD) is an example for a complex field of research, which is driven by themultifactorial etiology, the heterogeneity in phenotype and the variability in disease progression,as well as the presence of a long pre-diagnostic period, called prodromal PD, lasting up to decades(Postuma et al., 2010). The very slow, so far inevitably progressive, neurodegenerative process andthe multidimensional heterogeneity of symptoms in kind (motor and non-motor), time of onsetand speed of progression call for prediction markers and progression markers to understand theonset of neurodegeneration and its course. These markers would also help to establish endpointsfor neuroprotective treatment strategies aiming to modify disease progression. Because of thecomplexity, heterogeneity, and the progressive nature of PD, such predictive and progressionmarkers can only be identified in large cohorts and in studies with a longitudinal design.
4950  https://doi.org/10.3389/fnagi.2016.00121$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:8-publ-24249$xR$3Volltext$534
4961  https://macau.uni-kiel.de/receive/publ_mods_00002424
5051  610
5550  Biomarker
5550  Longitudinal Studies
5550  Modular Set
5550  Parkinson's Disease