6 documents found

Article / Chapter
CC BY-NC-ND 3.0
2018

Serum Inflammatory Profile for the Discrimination of Clinical Subtypes...

Background: Blood levels of immune markers have been proposed to discriminate patients with Parkinson's disease (PD) from controls. However, differences between clinical PD subgroups regarding these markers still need to be identified. Objective: To investigate whether clinical phenotypes can be predicted...
Lausanne: Frontiers Media SA, 2018
Article / Chapter
CC BY-NC-ND 3.0
2016

GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson’s Disease and...

Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be potential markers...
San Francisco: PloS one, 2016
Article / Chapter
CC BY-NC-ND 3.0
2016

Insulin-Like Growth Factor 1 (IGF-1) in Parkinson's Disease: Potential...

Introduction Biomarkers indicating trait, progression and prediction of pathology and symptoms in Parkinson's disease (PD) often lack specificity or reliability. Investigating biomarker variance between individuals and over time and the effect of confounding factors is essential for the evaluation...
San Francisco: PloS one, 2016
Article / Chapter
CC BY-NC-ND 3.0
2016

Inflammatory profile in LRRK2-associated prodromal and clinical PD

BACKGROUND There is evidence for a relevant role of inflammation in the pathogenesis of Parkinson's disease (PD). Mutations in the LRRK2 gene represent the most frequent genetic cause for autosomal dominant PD. LRRK2 is highly expressed in macrophages and microglia suggesting an involvement in inflammatory...
London: BioMed Central, 2016
Article / Chapter
CC BY-NC-ND 3.0
2014

Comparable Autoantibody Serum Levels against Amyloid- and Inflammation-Associated...

Naturally occurring autoantibodies (NAbs) against a number of potentially disease-associated cellular proteins, including Amyloid-beta1-42 (Abeta1-42), Alpha-synuclein (Asyn), myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and S100 calcium binding protein B (S100B) have been suggested...
San Francisco: PloS one, 2014
Article / Chapter
CC BY-NC-ND 3.0
2012

Serum and Cerebrospinal Fluid Levels of Transthyretin in Lewy Body Disorders...

Parkinson’s disease (PD) without (non-demented, PDND) and with dementia (PDD), and dementia with Lewy bodies (DLB) are subsumed under the umbrella term Lewy body disorders (LBD). The main component of the underlying pathologic substrate, i.e. Lewy bodies and Lewy neurites, is misfolded alpha-synuclein...
San Francisco: PloS one, 2012