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Dissertation

Analyse der NOD2-abhängigen Transkriptomregulation und Hemmung der NOD2-Aktivität...

NOD2 is an intracellular receptor for the bacterial cell wall component, muramyl dipeptide. Activation of NOD2 induces a complex inflammatory and antibacterial cellular program. Mutations in the leucine-rich repeat region of NOD2, which lead to an impaired recognition of muramyl-dipeptide (MDP), have...