9 documents found

Article / Chapter
CC BY-NC-ND 3.0
2018

Arm swing asymmetry in overground walking.

Treadmill experiments suggest that left-dominant arm swing is common in healthy walking adults and is modulated by cognitive dual-tasking. Little is known about arm swing asymmetry in overground walking. We report directional (dASI) and non-directional arm swing symmetry indices (ndASI) from 334 adults...
London: Springer Nature Publishing AG, 2018
Article / Chapter
CC BY-NC-ND 3.0
2017

Dual-Task Performance in GBA Parkinson’s Disease

INTRODUCTION Parkinson's disease patients carrying a heterozygous mutation in the geneglucocerebrosidase(GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson's disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT)...
London: Hindawi, 2017
Article / Chapter
CC BY-NC-ND 3.0
2016

GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson’s Disease and...

Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be potential markers...
San Francisco: PloS one, 2016
Article / Chapter
CC BY-NC-ND 3.0
2016

Inflammatory profile in LRRK2-associated prodromal and clinical PD

BACKGROUND There is evidence for a relevant role of inflammation in the pathogenesis of Parkinson's disease (PD). Mutations in the LRRK2 gene represent the most frequent genetic cause for autosomal dominant PD. LRRK2 is highly expressed in macrophages and microglia suggesting an involvement in inflammatory...
London: BioMed Central, 2016
Article / Chapter
CC BY-NC-ND 3.0
2015

Age and Vascular Burden Determinants of Cortical Hemodynamics Underlying...

BACKGROUND Aging processes and several vascular burden factors have been shown to increase the risk of dementia including Alzheimer's disease. While pathological alterations in dementia precede diagnosis by many years, reorganization of brain processing might temporarily delay cognitive decline. We hypothesized...
San Francisco: PloS one, 2015
Article / Chapter
CC BY-NC-ND 3.0
2015

Association between vestibulo-ocular reflex suppression, balance, gait,...

BACKGROUND Falls frequency increases with age and particularly in neurogeriatric cohorts. The interplay between eye movements and locomotion may contribute substantially to the occurrence of falls, but is hardly investigated. This paper provides an overview of current approaches to simultaneously measure...
London: BioMed Central, 2015
Article / Chapter
CC BY-NC-ND 3.0
2014

Mild Parkinsonian Signs in the Elderly – Is There an Association with PD?...

Background: Mild parkinsonian signs (MPS) are common in the elderly population, and have been associated with vascular diseases, mild cognitive impairment and dementia; however their relation to Parkinson’s disease (PD) is unclear. Hypothesizing that individuals with MPS may reflect a pre-stage of...
San Francisco: PloS one, 2014
Article / Chapter
CC BY-NC-ND 3.0
2014

A Neurodegenerative Vascular Burden Index and the Impact on Cognition

Lausanne: Frontiers Media SA, 2014
Article / Chapter
CC BY-NC-ND 3.0
2011

Poor Trail Making Test Performance Is Directly Associated with Altered...

Background: Deterioration of executive functions in the elderly has been associated with impairments in walking performance. This may be caused by limited cognitive flexibility and working memory, but could also be caused by altered prioritization of simultaneously performed tasks. To disentangle these...
San Francisco: PloS one, 2011