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Dissertation

Apoptosis is a natural stimulus of IL-6R shedding and contributes to the...

Interleukin-6 (IL-6) trans-signalling has emerged as a prominent regulator of immune responses during both innate and acquired immunity. Regulation of IL-6 trans-signalling is reliant upon the release of soluble IL-6R (sIL-6R), which binds IL-6 to create an agonistic IL-6/sIL-6R complex capable of activating...