7 documents found

Article / Chapter
CC BY-NC-ND 3.0
2018

Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's...

Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics...
Lausanne: Frontiers Media SA, 2018
Article / Chapter
CC BY-NC-ND 3.0
2016

GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson’s Disease and...

Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be potential markers...
San Francisco: PloS one, 2016
Article / Chapter
CC BY-NC-ND 3.0
2016

Insulin-Like Growth Factor 1 (IGF-1) in Parkinson's Disease: Potential...

Introduction Biomarkers indicating trait, progression and prediction of pathology and symptoms in Parkinson's disease (PD) often lack specificity or reliability. Investigating biomarker variance between individuals and over time and the effect of confounding factors is essential for the evaluation...
San Francisco: PloS one, 2016
Article / Chapter
CC BY-NC-ND 3.0
2014

Naturally Occurring Alpha-Synuclein Autoantibodies in Parkinson’s Disease:...

Alpha-synuclein ($α$-Syn) plays a pivotal role in the pathophysiology of Parkinson's disease (PD), which can partly be modulated by innate and adaptive immune functions, and vice versa. Here, naturally occurring $α$-Syn autoantibodies ($α$-Syn-nAbs) may be effective against $α$-Syn pathoetiology and...
San Francisco: PloS one, 2014
Article / Chapter
CC BY-NC-ND 3.0
2014

Comparable Autoantibody Serum Levels against Amyloid- and Inflammation-Associated...

Naturally occurring autoantibodies (NAbs) against a number of potentially disease-associated cellular proteins, including Amyloid-beta1-42 (Abeta1-42), Alpha-synuclein (Asyn), myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and S100 calcium binding protein B (S100B) have been suggested...
San Francisco: PloS one, 2014
Article / Chapter
CC BY-NC-ND 3.0
2012

Serum and Cerebrospinal Fluid Levels of Transthyretin in Lewy Body Disorders...

Parkinson’s disease (PD) without (non-demented, PDND) and with dementia (PDD), and dementia with Lewy bodies (DLB) are subsumed under the umbrella term Lewy body disorders (LBD). The main component of the underlying pathologic substrate, i.e. Lewy bodies and Lewy neurites, is misfolded alpha-synuclein...
San Francisco: PloS one, 2012