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The highly polymorphic HLA genes play a key role in adaptive immunity. The dynamic action of pathogen-mediated selection is proposed to be a major driver of HLA diversity, which involves parallel mechanisms acting at different time scales. Divergent HLA allelic lineages are proposed to be maintained...
The cell-surface molecules encoded by the genes of Human Leukocyte Antigen (HLA) present peptides to T-cells, which upon recognizing them as foreign, initiate a specific immune response. HLA genes have been associated with a variety of infectious and autoimmune diseases. However, the exact mechanisms...