2 documents found

Dissertation
Short version

Evolution and function of adaptive immunogenetic diversity in humans

The highly polymorphic HLA genes play a key role in adaptive immunity. The dynamic action of pathogen-mediated selection is proposed to be a major driver of HLA diversity, which involves parallel mechanisms acting at different time scales. Divergent HLA allelic lineages are proposed to be maintained...
Dissertation
Short version

Functional characterization of antigen repertoires in HLA-associated complex...

The cell-surface molecules encoded by the genes of Human Leukocyte Antigen (HLA) present peptides to T-cells, which upon recognizing them as foreign, initiate a specific immune response. HLA genes have been associated with a variety of infectious and autoimmune diseases. However, the exact mechanisms...