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Dissertation
Short version

Role of DNA methyltransferase 3A (DNMT3A) in intestinal epithelial cells...

This thesis investigates the role of DNMT3A in regulation, via its DNA methyltransferase activity,the transcriptome and methylome profile of intestinal epithelial cells. In addition, the consequences of the lack of DNMT3A on the functionality of the epithelial barrier was evaluated in vitro and in vivo...