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Dissertation
Short version

The role of the intramembrane protease SPPL2a and its substrate CD74 in...

In summary, SPPL2a–deficiency affects DC development and function in a CD74–dependent manner with important consequences on their ability to clear mycobacterial infections. The altered surface abundance of PRR receptors and the disturbed cytokine response observed in SPPL2a-/- BMDCs possibly contributes...