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Dissertation

Processing of CD74 by the intramembrane protease SPPL2a in B cells : Impact...

The intramembrane protease SPPL2a mediates the processing of transmembrane proteins in type II orientation. As the first in vivo validated substrate of this protease CD74 (invariant chain) was revealed. It functions as chaperone in MHCII-mediated antigen presentation. In the late endosomal membrane,...