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Dissertation

Identification of microRNAs as potential novel regulators of HSD11B1 expression

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1, gene name HSD11B1) is a ubiquitously expressed enzyme that converts glucocorticoid receptor-inert cortisone to receptor-active cortisol. HSD11B1 expression is regulated in a highly tissue-specific manner by immunomodulatory and metabolic regulators....