42 documents found

Article / Chapter
CC BY-NC-ND 3.0
2018

Are Hypometric Anticipatory Postural Adjustments Contributing to Freezing...

Introduction: This study aims at investigating whether impaired anticipatory postural adjustments (APA) during gait initiation contribute to the occurrence of freezing of gait (FOG) or whether altered APAs compensate for FOG in Parkinson's disease (PD).Methods:Gait initiation after 30 s quiet stance...
Lausanne: Frontiers Media SA, 2018
Article / Chapter
CC BY-NC-ND 3.0
2018

Serum Inflammatory Profile for the Discrimination of Clinical Subtypes...

Background: Blood levels of immune markers have been proposed to discriminate patients with Parkinson's disease (PD) from controls. However, differences between clinical PD subgroups regarding these markers still need to be identified. Objective: To investigate whether clinical phenotypes can be predicted...
Lausanne: Frontiers Media SA, 2018
Article / Chapter
CC BY-NC-ND 3.0
2018

Evaluation of cerebrospinal fluid proteins as potential biomarkers for...

Cerebrospinal fluid (CSF) has often been used as the source of choice for biomarker discovery with the goal to support the diagnosis of neurodegenerative diseases. For this study, we selected 15 CSF protein markers which were identified in previously published clinical investigations and proposed as...
San Francisco: PloS one, 2018
Article / Chapter
CC BY-NC-ND 3.0
2018

Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's...

Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics...
Lausanne: Frontiers Media SA, 2018
Article / Chapter
CC BY-NC-ND 3.0
2018

Moderate Frequency Resistance and Balance Training Do Not Improve Freezing...

Background and Aim: Individuals with Parkinson's disease (PD) and Freezing of Gait (FOG) have impaired postural control, which relate to the severity of FOG. The aim of this study was to analyze whether a moderate frequency resistance (RT) and balance training (BT), respectively, are effective to diminish...
Lausanne: Frontiers Media SA, 2018
Article / Chapter
CC BY-NC-ND 3.0
2018

Validation of a Lower Back “Wearable”-Based Sit-to-Stand and Stand-to-Sit...

Introduction: Impaired sit-to-stand and stand-to-sit movements (postural transitions, PTs) in patients with Parkinson’s disease (PD) and older adults (OA) are associated with risk of falling and reduced quality of life. Inertial measurement units (IMUs, also called “wearables”) are powerful tools...
Lausanne: Frontiers Media SA, 2018
Article / Chapter
CC BY-NC-ND 3.0
2018

Arm swing asymmetry in overground walking.

Treadmill experiments suggest that left-dominant arm swing is common in healthy walking adults and is modulated by cognitive dual-tasking. Little is known about arm swing asymmetry in overground walking. We report directional (dASI) and non-directional arm swing symmetry indices (ndASI) from 334 adults...
London: Springer Nature Publishing AG, 2018
Article / Chapter
CC BY-NC-ND 3.0
2018

Effect of Fear of Falling on Turning Performance in Parkinson's Disease...

Background: Parkinson's disease (PD) is a neurodegenerative movement disorder associated with gait and balance problems and a substantially increased risk of falling. Falls occur often during complex movements, such as turns. Both fear of falling (FOF) and previous falls are relevant risk factors for...
Lausanne: Frontiers Media SA, 2018
Article / Chapter
CC BY-NC-ND 3.0
2018

Biomarkers of Neurodegeneration in Autoimmune-Mediated Encephalitis.

Progranulin (PGRN), Total-Tau (t-tau), and Neurofilament light chain (NfL) are well known biomarkers of neurodegeneration. The objective of the present study was to investigate whether these parameters represent also biomarkers in autoimmune-mediated Encephalitis (AE) and may give us insights into the...
Lausanne: Frontiers Media SA, 2018
Article / Chapter
CC BY-NC-ND 3.0
2018

Do We Need to Rethink the Epidemiology and Healthcare Utilization of Parkinson's...

Epidemiological aspects of Parkinson's disease (PD), co-occurring diseases and medical healthcare utilization of PD patients are still largely elusive. Based on claims data of 3.7 million statutory insurance members in Germany in 2015 the prevalence and incidence of PD was determined. PD cases had at...
Lausanne: Frontiers Media SA, 2018
Article / Chapter
CC BY-NC-ND 3.0
2018

Cholinergic Pathway SNPs and Postural Control in 477 Older Adults.

Objective: To determine whether single nucleotide polymorphisms (SNPs) of the cholinergic system and quantitative parameters of postural control are associated in healthy older adults. This is a cross-sectional analysis from the TREND study. Methods: All participants performed a static postural control...
Lausanne: Frontiers Media SA, 2018
Article / Chapter
CC BY-NC-ND 3.0
2018

Wearables for gait and balance assessment in the neurological ward - study...

Deficits in gait and balance are common among neurological inpatients. Currently, assessment of these patients is mainly subjective. New assessment options using wearables may provide complementary and more objective information. In this prospective cross-sectional feasibility study performed over...
London: Springer Nature Publishing AG, 2018
Article / Chapter
CC BY-NC-ND 3.0
2017

The release and trans-synaptic transmission of Tau via exosomes

BACKGROUND Tau pathology in AD spreads in a hierarchical pattern, whereby it first appears in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding areas. Based on this sequential appearance, AD can be classified into six stages ("Braak stages"). The mechanisms and agents...
London: BioMed Central, 2017
Article / Chapter
CC BY-NC-ND 3.0
2017

Gait Is Associated with Cognitive Flexibility: A Dual-Tasking Study in...

Objectives: To analyze which gait parameters are primarily influenced by cognitive flexibility, and whether such an effect depends on the walking condition used. Design: Cross-sectional analysis. Setting: Tübingen evaluation of Risk factors for Early detection of Neurodegenerative Disorders. Participants:...
Lausanne: Frontiers Media SA, 2017
Article / Chapter
CC BY-NC-ND 3.0
2017

Dual-Task Performance in GBA Parkinson’s Disease

INTRODUCTION Parkinson's disease patients carrying a heterozygous mutation in the geneglucocerebrosidase(GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson's disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT)...
London: Hindawi, 2017
Article / Chapter
CC BY-NC-ND 3.0
2017

No relevant association of kinematic gait parameters with Health-related...

BACKGROUND Health-related Quality of Life (HrQoL) is probably the most important outcome parameter for the evaluation and management of chronic diseases. As this parameter is subjective and prone to bias, there is an urgent need to identify objective surrogate markers. Gait velocity has been shown to...
San Francisco: PloS one, 2017
Article / Chapter
CC BY-NC-ND 3.0
2017

Corrigendum: White Matter Changes-Related Gait and Executive Function Deficits:...

[This corrects the article on p. 213 in vol. 9, PMID: 28713264.].
Lausanne: Frontiers Media SA, 2017
Article / Chapter
CC BY-NC-ND 3.0
2017

White Matter Changes-Related Gait and Executive Function Deficits: Associations...

Background: White matter changes (WMC) are a common finding among older adults and patients with Parkinson's disease (PD), and have been associated with, e.g., gait deficits and executive dysfunction. How the factors age and PD influence WMC-related deficits is, to our best knowledge, not investigated...
Lausanne: Frontiers Media SA, 2017
Article / Chapter
CC BY-NC-ND 3.0
2017

Algorithm for Turning Detection and Analysis Validated under Home-Like...

INTRODUCTION Aging and age-associated disorders such as Parkinson's disease (PD) are often associated with turning difficulties, which can lead to falls and fractures. Valid assessment of turning and turning deficits specifically in non-standardized environments may foster specific treatment and prevention...
Lausanne: Frontiers Media SA, 2017
Article / Chapter
2017

Validation of a Step Detection Algorithm during Straight Walking and Turning...

INTRODUCTION Inertial measurement units (IMUs) positioned on various body locations allow detailed gait analysis even under unconstrained conditions. From a medical perspective, the assessment of vulnerable populations is of particular relevance, especially in the daily-life environment. Gait analysis...
Lausanne: Frontiers Media SA, 2017