Dissertation (Metadaten)
Titel:A systematic genome-wide association analysis for inflammatory bowel diseases (IBD)
 
Autor:Andre Franke
 
URN:NBN:urn:nbn:de:gbv:8-diss-18728
 
Fakultät:Mathematisch-Naturwissenschaftliche Fakultät
DDC Sachgebiet:570 Biowissenschaften, Biologie
 
Datum der mdl. Prüfung:08.11.2006
 
Referent(in):Prof. Dr. Dr. T.C.G. Bosch
Korreferent(en) Korreferentin:Prof. Dr. S. Schreiber
 
Beschreibung:Two independent and hypothesis-free genome-wide association studies were carried out to find novel susceptibility genes for Crohn’s disease (CD), which is a chronic inflammatory disorder of the bowel. In a first sequence-based and “direct” scan, approximately 20,000 nonsynonymous SNPs, which result in a change in protein sequence, were typed. The second “indirect” map-based scan comprised about 100,000 evenly distributed SNPs.
 
Schlagworte:Inflammatory Bowel Diseases, Crohn's disease, association study, Linkage disequilibrium, autophagy, ATG16L1, CARD15, genome-wide,
 
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