Psychobiologische Belastungsparameter bei Personen mit chronisch-rezidivierender atopischer Dermatitis unter Berücksichtigung des aktuellen Symptomstatus
Adult patients suffering from atopic dermatitis (AD) were investigated for their psycho-physiologic reactions to stress. All patients were investigated twice in the symptom-free interval and when they had acute inflammations. En-hanced psychic distress could only be demonstrated in patients with acute inflammations. In patients with acute symptoms systolic blood pressure increased more than in patients without acute symptoms or in controls. The hy-pothesis of reduced basal levels of cortisol or reduced secretion due to acute experimental stress in AD-patients could not be confirmed. In patients with symptoms in remis-sion the stress induced secretion of cortisol was enhanced. Depending on the status of symptoms the results indicate an imbalance between catecholamin-induced activation and HPA-activation in AD-patients. Considering central stress-regulation-systems and possible interactions with the Skin-Stress-Response-System both, enhanced cortisol release in patients with remitted symptoms and increased sympathetic activation in patients with acute inflammatory lesions might be a risk factor in the immunomodulation of AD.
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